EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000256223 ZNF10 H. sapiens SDL Slorth 0.944435 View
ENSG00000146648 EGFR ENSG00000215301 DDX3X H. sapiens SSL Slorth 0.944379 View
ENSG00000146648 EGFR ENSG00000168002 POLR2G H. sapiens SDL Slorth 0.944345 View
ENSG00000126561 STAT5A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944302 View
ENSG00000070010 UFD1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944117 View
ENSG00000113578 FGF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944079 View
ENSG00000109458 GAB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944065 View
ENSG00000076555 ACACB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944021 View
ENSG00000146648 EGFR ENSG00000168556 ING2 H. sapiens SSL Slorth 0.943949 View
ENSG00000146648 EGFR ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.943946 View
ENSG00000125618 PAX8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.943939 View
ENSG00000140396 NCOA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.943845 View
ENSG00000097046 CDC7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.943775 View
ENSG00000146648 EGFR ENSG00000242247 ARFGAP3 H. sapiens SDL Slorth 0.943685 View
ENSG00000146648 EGFR ENSG00000198700 IPO9 H. sapiens SSL Slorth 0.943483 View
ENSG00000146648 EGFR ENSG00000164045 CDC25A H. sapiens SDL Slorth 0.943469 View
ENSG00000146648 EGFR ENSG00000160803 UBQLN4 H. sapiens SDL Slorth 0.943391 View
ENSG00000101460 MAP1LC3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.943378 View
ENSG00000086200 IPO11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94324 View
ENSG00000146648 EGFR ENSG00000243678 NME2 H. sapiens SDL Slorth 0.943233 View
ENSG00000146648 EGFR ENSG00000165731 RET H. sapiens SSL Slorth 0.943231 View
ENSG00000146648 EGFR ENSG00000156508 EEF1A1 H. sapiens SSL Slorth 0.943214 View
ENSG00000125630 POLR1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.943198 View
ENSG00000058056 USP13 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94311 View
ENSG00000146648 EGFR ENSG00000148516 ZEB1 H. sapiens SDL Slorth 0.942899 View
ENSG00000146648 EGFR ENSG00000172845 SP3 H. sapiens SSL Slorth 0.942866 View
ENSG00000146648 EGFR ENSG00000185338 SOCS1 H. sapiens SSL Slorth 0.94282 View
ENSG00000141582 CBX4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94278 View
ENSG00000146648 EGFR ENSG00000184634 MED12 H. sapiens SSL Slorth 0.942633 View
ENSG00000089053 ANAPC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.942615 View
ENSG00000144848 ATG3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94261 View
ENSG00000146648 EGFR ENSG00000167553 TUBA1C H. sapiens SSL Slorth 0.942546 View
ENSG00000146648 EGFR ENSG00000161203 AP2M1 H. sapiens SSL Slorth 0.942543 View
ENSG00000146648 EGFR ENSG00000157227 MMP14 H. sapiens SDL Slorth 0.942526 View
ENSG00000146648 EGFR ENSG00000198911 SREBF2 H. sapiens SSL Slorth 0.942367 View
ENSG00000146648 EGFR ENSG00000171105 INSR H. sapiens SSL Slorth 0.942209 View
ENSG00000118689 FOXO3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.942174 View
ENSG00000146648 EGFR ENSG00000168906 MAT2A H. sapiens SDL Slorth 0.941979 View
ENSG00000113263 ITK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941951 View
ENSG00000146648 EGFR ENSG00000177426 TGIF1 H. sapiens SDL Slorth 0.941933 View