EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000069399 BCL3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940731 View
ENSG00000146648 EGFR ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.940683 View
ENSG00000096063 SRPK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940546 View
ENSG00000064393 HIPK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940545 View
ENSG00000133119 RFC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940501 View
ENSG00000146648 EGFR ENSG00000182866 LCK H. sapiens SSL Slorth 0.940426 View
ENSG00000114302 PRKAR2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940352 View
ENSG00000146648 EGFR ENSG00000178950 GAK H. sapiens SSL Slorth 0.940335 View
ENSG00000134287 ARF3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940332 View
ENSG00000146648 EGFR ENSG00000169750 RAC3 H. sapiens SSL Slorth 0.940287 View
ENSG00000065054 SLC9A3R2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.940187 View
ENSG00000146648 EGFR ENSG00000198380 GFPT1 H. sapiens SDL Slorth 0.940147 View
ENSG00000146648 EGFR ENSG00000176248 ANAPC2 H. sapiens SDL Slorth 0.94004 View
ENSG00000136527 TRA2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939983 View
ENSG00000146648 EGFR ENSG00000156603 MED19 H. sapiens SDL Slorth 0.939927 View
ENSG00000070831 CDC42 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939883 View
ENSG00000117569 PTBP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939876 View
ENSG00000146648 EGFR ENSG00000175197 DDIT3 H. sapiens SSL Slorth 0.939794 View
ENSG00000065135 GNAI3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939632 View
ENSG00000146648 EGFR ENSG00000198258 UBL5 H. sapiens SSL Slorth 0.939616 View
ENSG00000100029 PES1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939585 View
ENSG00000145715 RASA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939546 View
ENSG00000146648 EGFR ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.939478 View
ENSG00000138376 BARD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939398 View
ENSG00000146648 EGFR ENSG00000166797 FAM96A H. sapiens SDL Slorth 0.939293 View
ENSG00000108424 KPNB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939288 View
ENSG00000104881 PPP1R13L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.93927 View
ENSG00000091831 ESR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.939131 View
ENSG00000146648 EGFR ENSG00000162775 RBM15 H. sapiens SDL Slorth 0.939061 View
ENSG00000146648 EGFR ENSG00000159251 ACTC1 H. sapiens SSL Slorth 0.939016 View
ENSG00000146648 EGFR ENSG00000183580 FBXL7 H. sapiens SDL Slorth 0.939008 View
ENSG00000146648 EGFR ENSG00000151348 EXT2 H. sapiens SDL Slorth 0.938999 View
ENSG00000143632 ACTA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938934 View
ENSG00000146648 EGFR ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.938924 View
ENSG00000144749 LRIG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938861 View
ENSG00000146648 EGFR ENSG00000169800 RBMY1F H. sapiens SDL Slorth 0.938811 View
ENSG00000146648 EGFR ENSG00000196419 XRCC6 H. sapiens SSL Slorth 0.938706 View
ENSG00000103479 RBL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938663 View
ENSG00000146648 EGFR ENSG00000188375 H3F3C H. sapiens SDL Slorth 0.938532 View
ENSG00000146648 EGFR ENSG00000147164 SNX12 H. sapiens SDL Slorth 0.938532 View