EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000118058 KMT2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935976 View
ENSG00000146648 EGFR ENSG00000198517 MAFK H. sapiens SDL Slorth 0.935936 View
ENSG00000141968 VAV1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935923 View
ENSG00000146648 EGFR ENSG00000165392 WRN H. sapiens SSL Slorth 0.935873 View
ENSG00000108953 YWHAE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935872 View
ENSG00000146648 EGFR ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.935836 View
ENSG00000146648 EGFR ENSG00000198373 WWP2 H. sapiens SSL Slorth 0.935774 View
ENSG00000146648 EGFR ENSG00000175104 TRAF6 H. sapiens SDL Slorth 0.935722 View
ENSG00000146648 EGFR ENSG00000151247 EIF4E H. sapiens SSL Slorth 0.935618 View
ENSG00000146648 EGFR ENSG00000169696 ASPSCR1 H. sapiens SDL Slorth 0.935495 View
ENSG00000146648 EGFR ENSG00000170144 HNRNPA3 H. sapiens SDL Slorth 0.93548 View
ENSG00000095015 MAP3K1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935431 View
ENSG00000102054 RBBP7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935371 View
ENSG00000134602 STK26 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935348 View
ENSG00000146648 EGFR ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.935232 View
ENSG00000146648 EGFR ENSG00000184432 COPB2 H. sapiens SSL Slorth 0.935224 View
ENSG00000146648 EGFR ENSG00000177189 RPS6KA3 H. sapiens SSL Slorth 0.935198 View
ENSG00000110799 VWF ENSG00000146648 EGFR H. sapiens SDL Slorth 0.93517 View
ENSG00000146648 EGFR ENSG00000148843 PDCD11 H. sapiens SDL Slorth 0.935104 View
ENSG00000146648 EGFR ENSG00000165025 SYK H. sapiens SSL Slorth 0.935085 View
ENSG00000121022 COPS5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935027 View
ENSG00000146648 EGFR ENSG00000175387 SMAD2 H. sapiens SDL Slorth 0.934922 View
ENSG00000146648 EGFR ENSG00000163947 ARHGEF3 H. sapiens SDL Slorth 0.934759 View
ENSG00000034713 GABARAPL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.934677 View
ENSG00000146648 EGFR ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.934608 View
ENSG00000146648 EGFR ENSG00000198677 TTC37 H. sapiens SSL Slorth 0.934577 View
ENSG00000106089 STX1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.934493 View
ENSG00000146648 EGFR ENSG00000178394 HTR1A H. sapiens SDL Slorth 0.934451 View
ENSG00000146648 EGFR ENSG00000179262 RAD23A H. sapiens SDL Slorth 0.934438 View
ENSG00000082397 EPB41L3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.934428 View
ENSG00000146648 EGFR ENSG00000196218 RYR1 H. sapiens SDL Slorth 0.934364 View
ENSG00000007047 MARK4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.93423 View
ENSG00000123416 TUBA1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.934204 View
ENSG00000116017 ARID3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.934173 View
ENSG00000146648 EGFR ENSG00000198719 DLL1 H. sapiens SSL Slorth 0.934122 View
ENSG00000146648 EGFR ENSG00000150457 LATS2 H. sapiens SSL Slorth 0.934088 View
ENSG00000146648 EGFR ENSG00000198947 DMD H. sapiens SSL Slorth 0.934087 View
ENSG00000146648 EGFR ENSG00000196262 PPIA H. sapiens SSL Slorth 0.934086 View
ENSG00000146648 EGFR ENSG00000163466 ARPC2 H. sapiens SDL Slorth 0.93405 View
ENSG00000116062 MSH6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.933811 View