EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000112290 WASF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938481 View
ENSG00000146648 EGFR ENSG00000163098 BIRC8 H. sapiens SDL Slorth 0.938423 View
ENSG00000146648 EGFR ENSG00000152086 TUBA3E H. sapiens SSL Slorth 0.938414 View
ENSG00000146648 EGFR ENSG00000161542 PRPSAP1 H. sapiens SDL Slorth 0.938364 View
ENSG00000146648 EGFR ENSG00000147224 PRPS1 H. sapiens SDL Slorth 0.938364 View
ENSG00000143190 POU2F1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938281 View
ENSG00000146648 EGFR ENSG00000160803 UBQLN4 H. sapiens SSL Slorth 0.938234 View
ENSG00000146648 EGFR ENSG00000213079 SCAF8 H. sapiens SDL Slorth 0.938196 View
ENSG00000129315 CCNT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938182 View
ENSG00000146648 EGFR ENSG00000180370 PAK2 H. sapiens SSL Slorth 0.938177 View
ENSG00000070018 LRP6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.93815 View
ENSG00000072310 SREBF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.938138 View
ENSG00000146648 EGFR ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.938055 View
ENSG00000146648 EGFR ENSG00000172409 CLP1 H. sapiens SDL Slorth 0.937965 View
ENSG00000146648 EGFR ENSG00000185104 FAF1 H. sapiens SSL Slorth 0.937857 View
ENSG00000146648 EGFR ENSG00000172409 CLP1 H. sapiens SSL Slorth 0.937681 View
ENSG00000146648 EGFR ENSG00000172534 HCFC1 H. sapiens SSL Slorth 0.937501 View
ENSG00000146648 EGFR ENSG00000162298 SYVN1 H. sapiens SDL Slorth 0.937389 View
ENSG00000131467 PSME3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.937372 View
ENSG00000146648 EGFR ENSG00000198087 CD2AP H. sapiens SSL Slorth 0.937315 View
ENSG00000033800 PIAS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.937294 View
ENSG00000146648 EGFR ENSG00000247596 TWF2 H. sapiens SDL Slorth 0.937257 View
ENSG00000146648 EGFR ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.937122 View
ENSG00000146648 EGFR ENSG00000245848 CEBPA H. sapiens SSL Slorth 0.937083 View
ENSG00000146648 EGFR ENSG00000147573 TRIM55 H. sapiens SSL Slorth 0.937056 View
ENSG00000146648 EGFR ENSG00000164109 MAD2L1 H. sapiens SSL Slorth 0.937052 View
ENSG00000106299 WASL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936977 View
ENSG00000082898 XPO1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936816 View
ENSG00000125676 THOC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936731 View
ENSG00000112039 FANCE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936693 View
ENSG00000146648 EGFR ENSG00000254505 CHMP4A H. sapiens SDL Slorth 0.936646 View
ENSG00000126215 XRCC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936577 View
ENSG00000146648 EGFR ENSG00000198612 COPS8 H. sapiens SSL Slorth 0.936498 View
ENSG00000115163 CENPA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936474 View
ENSG00000146648 EGFR ENSG00000149480 MTA2 H. sapiens SSL Slorth 0.936359 View
ENSG00000146648 EGFR ENSG00000151239 TWF1 H. sapiens SDL Slorth 0.936312 View
ENSG00000126457 PRMT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.936076 View
ENSG00000146648 EGFR ENSG00000177666 PNPLA2 H. sapiens SDL Slorth 0.935986 View
ENSG00000136986 DERL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935982 View
ENSG00000135521 LTV1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.935978 View