EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000103657 HERC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951823 View
ENSG00000114491 UMPS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951823 View
ENSG00000112245 PTP4A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951823 View
ENSG00000126453 BCL2L12 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951823 View
ENSG00000073282 TP63 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951801 View
ENSG00000141736 ERBB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951696 View
ENSG00000084072 PPIE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951682 View
ENSG00000138696 BMPR1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951604 View
ENSG00000146648 EGFR ENSG00000171791 BCL2 H. sapiens SDL Slorth 0.951595 View
ENSG00000106628 POLD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951536 View
ENSG00000146648 EGFR ENSG00000198561 CTNND1 H. sapiens SSL Slorth 0.95148 View
ENSG00000146648 EGFR ENSG00000149925 ALDOA H. sapiens SDL Slorth 0.951479 View
ENSG00000091009 RBM27 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951449 View
ENSG00000119041 GTF3C3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951322 View
ENSG00000106070 GRB10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951265 View
ENSG00000146648 EGFR ENSG00000160200 CBS H. sapiens SDL Slorth 0.951201 View
ENSG00000146648 EGFR ENSG00000178607 ERN1 H. sapiens SSL Slorth 0.951173 View
ENSG00000146648 EGFR ENSG00000186575 NF2 H. sapiens SSL Slorth 0.951162 View
ENSG00000146648 EGFR ENSG00000188021 UBQLN2 H. sapiens SSL Slorth 0.951159 View
ENSG00000005175 RPAP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95114 View
ENSG00000123975 CKS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95107 View
ENSG00000146648 EGFR ENSG00000175792 RUVBL1 H. sapiens SDL Slorth 0.951026 View
ENSG00000146648 EGFR ENSG00000183791 TCEB3C H. sapiens SDL Slorth 0.950993 View
ENSG00000125845 BMP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95099 View
ENSG00000113916 BCL6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950961 View
ENSG00000105656 ELL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950928 View
ENSG00000145782 ATG12 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950925 View
ENSG00000099956 SMARCB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95083 View
ENSG00000146648 EGFR ENSG00000198055 GRK6 H. sapiens SDL Slorth 0.950787 View
ENSG00000146648 EGFR ENSG00000186625 KATNA1 H. sapiens SDL Slorth 0.950787 View
ENSG00000146648 EGFR ENSG00000169067 ACTBL2 H. sapiens SDL Slorth 0.950787 View
ENSG00000146648 EGFR ENSG00000169118 CSNK1G1 H. sapiens SDL Slorth 0.950787 View
ENSG00000146648 EGFR ENSG00000162407 PLPP3 H. sapiens SDL Slorth 0.950787 View
ENSG00000146648 EGFR ENSG00000149782 PLCB3 H. sapiens SDL Slorth 0.950787 View
ENSG00000070367 EXOC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950706 View
ENSG00000072062 PRKACA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950693 View
ENSG00000146648 EGFR ENSG00000152669 CCNO H. sapiens SDL Slorth 0.950668 View
ENSG00000085415 SEH1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950631 View
ENSG00000109189 USP46 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950502 View
ENSG00000121879 PIK3CA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950471 View