EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000273841 TAF9 H. sapiens SDL Slorth 0.950324 View
ENSG00000146648 EGFR ENSG00000173039 RELA H. sapiens SDL Slorth 0.950304 View
ENSG00000146648 EGFR ENSG00000155974 GRIP1 H. sapiens SSL Slorth 0.950284 View
ENSG00000146648 EGFR ENSG00000164362 TERT H. sapiens SSL Slorth 0.950253 View
ENSG00000064012 CASP8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950251 View
ENSG00000108821 COL1A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950246 View
ENSG00000146648 EGFR ENSG00000188130 MAPK12 H. sapiens SDL Slorth 0.950227 View
ENSG00000091136 LAMB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950108 View
ENSG00000132388 UBE2G1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950093 View
ENSG00000146648 EGFR ENSG00000164924 YWHAZ H. sapiens SDL Slorth 0.95007 View
ENSG00000135333 EPHA7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.950044 View
ENSG00000146648 EGFR ENSG00000253729 PRKDC H. sapiens SDL Slorth 0.949994 View
ENSG00000136068 FLNB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949982 View
ENSG00000144645 OSBPL10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949918 View
ENSG00000100485 SOS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949844 View
ENSG00000146648 EGFR ENSG00000166501 PRKCB H. sapiens SSL Slorth 0.949777 View
ENSG00000146648 EGFR ENSG00000149269 PAK1 H. sapiens SDL Slorth 0.949727 View
ENSG00000125814 NAPB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949666 View
ENSG00000146648 EGFR ENSG00000197275 RAD54B H. sapiens SDL Slorth 0.949488 View
ENSG00000146648 EGFR ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.949459 View
ENSG00000113595 TRIM23 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949409 View
ENSG00000140990 NDUFB10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949389 View
ENSG00000110713 NUP98 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949299 View
ENSG00000105639 JAK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949281 View
ENSG00000146648 EGFR ENSG00000184900 SUMO3 H. sapiens SDL Slorth 0.949188 View
ENSG00000018625 ATP1A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949127 View
ENSG00000138031 ADCY3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949127 View
ENSG00000141458 NPC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949127 View
ENSG00000102879 CORO1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949127 View
ENSG00000146648 EGFR ENSG00000197969 VPS13A H. sapiens SDL Slorth 0.949075 View
ENSG00000146648 EGFR ENSG00000168827 GFM1 H. sapiens SDL Slorth 0.949075 View
ENSG00000146648 EGFR ENSG00000164164 OTUD4 H. sapiens SDL Slorth 0.949075 View
ENSG00000001626 CFTR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.949022 View
ENSG00000103342 GSPT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948968 View
ENSG00000146648 EGFR ENSG00000147010 SH3KBP1 H. sapiens SSL Slorth 0.948947 View
ENSG00000146648 EGFR ENSG00000241837 ATP5O H. sapiens SSL Slorth 0.948872 View
ENSG00000142675 CNKSR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948814 View
ENSG00000100034 PPM1F ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948762 View
ENSG00000136492 BRIP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948748 View
ENSG00000132326 PER2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948734 View