EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000135047 CTSL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946628 View
ENSG00000100201 DDX17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946584 View
ENSG00000070495 JMJD6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946516 View
ENSG00000124193 SRSF6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946491 View
ENSG00000146648 EGFR ENSG00000163902 RPN1 H. sapiens SSL Slorth 0.946453 View
ENSG00000108384 RAD51C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946384 View
ENSG00000104408 EIF3E ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946337 View
ENSG00000146648 EGFR ENSG00000183207 RUVBL2 H. sapiens SDL Slorth 0.94633 View
ENSG00000136878 USP20 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946227 View
ENSG00000146648 EGFR ENSG00000179295 PTPN11 H. sapiens SDL Slorth 0.946206 View
ENSG00000080824 HSP90AA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946181 View
ENSG00000107882 SUFU ENSG00000146648 EGFR H. sapiens SDL Slorth 0.946091 View
ENSG00000146648 EGFR ENSG00000184787 UBE2G2 H. sapiens SDL Slorth 0.946048 View
ENSG00000146648 EGFR ENSG00000162236 STX5 H. sapiens SDL Slorth 0.945991 View
ENSG00000146648 EGFR ENSG00000166226 CCT2 H. sapiens SDL Slorth 0.945912 View
ENSG00000146648 EGFR ENSG00000148737 TCF7L2 H. sapiens SSL Slorth 0.945881 View
ENSG00000146648 EGFR ENSG00000167085 PHB H. sapiens SSL Slorth 0.945827 View
ENSG00000065320 NTN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945718 View
ENSG00000117676 RPS6KA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945692 View
ENSG00000044524 EPHA3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945565 View
ENSG00000140416 TPM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945338 View
ENSG00000065665 SEC61A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945291 View
ENSG00000130382 MLLT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94525 View
ENSG00000119314 PTBP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945242 View
ENSG00000146648 EGFR ENSG00000254087 LYN H. sapiens SSL Slorth 0.945236 View
ENSG00000146648 EGFR ENSG00000154767 XPC H. sapiens SSL Slorth 0.945222 View
ENSG00000146648 EGFR ENSG00000168036 CTNNB1 H. sapiens SDL Slorth 0.945219 View
ENSG00000115866 DARS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945157 View
ENSG00000119866 BCL11A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94515 View
ENSG00000130522 JUND ENSG00000146648 EGFR H. sapiens SDL Slorth 0.945095 View
ENSG00000105649 RAB3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944856 View
ENSG00000146648 EGFR ENSG00000177169 ULK1 H. sapiens SDL Slorth 0.944787 View
ENSG00000146648 EGFR ENSG00000198382 UVRAG H. sapiens SDL Slorth 0.944764 View
ENSG00000146648 EGFR ENSG00000244687 UBE2V1 H. sapiens SDL Slorth 0.94476 View
ENSG00000143398 PIP5K1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944752 View
ENSG00000134954 ETS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944685 View
ENSG00000130985 UBA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944662 View
ENSG00000101224 CDC25B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.944649 View
ENSG00000146648 EGFR ENSG00000149923 PPP4C H. sapiens SDL Slorth 0.944596 View
ENSG00000146648 EGFR ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.944466 View