EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000085511 MAP3K4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948732 View
ENSG00000120156 TEK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948719 View
ENSG00000138182 KIF20B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948694 View
ENSG00000118193 KIF14 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948694 View
ENSG00000146648 EGFR ENSG00000170345 FOS H. sapiens SDL Slorth 0.948671 View
ENSG00000146648 EGFR ENSG00000185615 PDIA2 H. sapiens SDL Slorth 0.948655 View
ENSG00000131165 CHMP1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94861 View
ENSG00000135945 REV1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948569 View
ENSG00000115091 ACTR3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9485 View
ENSG00000146648 EGFR ENSG00000169139 UBE2V2 H. sapiens SSL Slorth 0.948476 View
ENSG00000078668 VDAC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948411 View
ENSG00000114354 TFG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948349 View
ENSG00000146648 EGFR ENSG00000198467 TPM2 H. sapiens SDL Slorth 0.948342 View
ENSG00000050820 BCAR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948329 View
ENSG00000111786 SRSF9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948243 View
ENSG00000143093 STRIP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.948077 View
ENSG00000146648 EGFR ENSG00000154832 CXXC1 H. sapiens SDL Slorth 0.948075 View
ENSG00000146648 EGFR ENSG00000161960 EIF4A1 H. sapiens SSL Slorth 0.948027 View
ENSG00000146648 EGFR ENSG00000181789 COPG1 H. sapiens SSL Slorth 0.947958 View
ENSG00000067955 CBFB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947945 View
ENSG00000034053 APBA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947766 View
ENSG00000146648 EGFR ENSG00000146731 CCT6A H. sapiens SDL Slorth 0.947729 View
ENSG00000100393 EP300 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947653 View
ENSG00000146648 EGFR ENSG00000148400 NOTCH1 H. sapiens SDL Slorth 0.947648 View
ENSG00000144036 EXOC6B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947647 View
ENSG00000146648 EGFR ENSG00000188215 DCUN1D3 H. sapiens SDL Slorth 0.947564 View
ENSG00000078747 ITCH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94752 View
ENSG00000112242 E2F3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947462 View
ENSG00000057663 ATG5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947427 View
ENSG00000113721 PDGFRB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94739 View
ENSG00000100664 EIF5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947344 View
ENSG00000122565 CBX3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947301 View
ENSG00000146648 EGFR ENSG00000178573 MAF H. sapiens SDL Slorth 0.947249 View
ENSG00000131263 RLIM ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947147 View
ENSG00000105723 GSK3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947132 View
ENSG00000008735 MAPK8IP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947112 View
ENSG00000112118 MCM3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.947051 View
ENSG00000101146 RAE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.94705 View
ENSG00000146648 EGFR ENSG00000177301 KCNA2 H. sapiens SDL Slorth 0.947032 View
ENSG00000146648 EGFR ENSG00000156304 SCAF4 H. sapiens SDL Slorth 0.94688 View