EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000128908 INO80 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941893 View
ENSG00000146648 EGFR ENSG00000147416 ATP6V1B2 H. sapiens SSL Slorth 0.941867 View
ENSG00000135018 UBQLN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941826 View
ENSG00000146648 EGFR ENSG00000197905 TEAD4 H. sapiens SDL Slorth 0.941796 View
ENSG00000134323 MYCN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941724 View
ENSG00000136854 STXBP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941716 View
ENSG00000146648 EGFR ENSG00000187627 RGPD1 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000239900 ADSL H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000277075 HIST1H2AE H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000197409 HIST1H3D H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000196862 RGPD4 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000153165 RGPD3 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000174840 PDE12 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000166965 RCCD1 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000174740 PABPC5 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000197238 HIST1H4J H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000169629 RGPD8 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000167778 SPRYD3 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000197894 ADH5 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000197136 PCNX3 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000149657 LSM14B H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000196950 SLC39A10 H. sapiens SDL Slorth 0.94165 View
ENSG00000146648 EGFR ENSG00000182054 IDH2 H. sapiens SDL Slorth 0.94165 View
ENSG00000135766 EGLN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941638 View
ENSG00000127824 TUBA4A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941602 View
ENSG00000146648 EGFR ENSG00000158169 FANCC H. sapiens SSL Slorth 0.941551 View
ENSG00000120805 ARL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941492 View
ENSG00000074201 CLNS1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941414 View
ENSG00000131828 PDHA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941393 View
ENSG00000114126 TFDP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941377 View
ENSG00000146648 EGFR ENSG00000158092 NCK1 H. sapiens SDL Slorth 0.941234 View
ENSG00000116957 TBCE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941176 View
ENSG00000101096 NFATC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941172 View
ENSG00000004700 RECQL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941108 View
ENSG00000090054 SPTLC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941092 View
ENSG00000102753 KPNA3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.941055 View
ENSG00000146648 EGFR ENSG00000153558 FBXL2 H. sapiens SDL Slorth 0.941032 View
ENSG00000146648 EGFR ENSG00000173120 KDM2A H. sapiens SDL Slorth 0.941015 View
ENSG00000146648 EGFR ENSG00000166266 CUL5 H. sapiens SDL Slorth 0.940888 View
ENSG00000146648 EGFR ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.940764 View