EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000173914 RBM4B H. sapiens SDL Slorth 0.9534 View
ENSG00000114867 EIF4G1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953372 View
ENSG00000078061 ARAF ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953342 View
ENSG00000146648 EGFR ENSG00000150593 PDCD4 H. sapiens SDL Slorth 0.953314 View
ENSG00000146648 EGFR ENSG00000160211 G6PD H. sapiens SDL Slorth 0.953211 View
ENSG00000146648 EGFR ENSG00000184743 ATL3 H. sapiens SDL Slorth 0.953211 View
ENSG00000116288 PARK7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953203 View
ENSG00000107341 UBE2R2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953183 View
ENSG00000036672 USP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953093 View
ENSG00000146648 EGFR ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.953084 View
ENSG00000146648 EGFR ENSG00000147316 MCPH1 H. sapiens SDL Slorth 0.952982 View
ENSG00000141522 ARHGDIA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952981 View
ENSG00000136450 SRSF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95291 View
ENSG00000146648 EGFR ENSG00000197122 SRC H. sapiens SDL Slorth 0.952841 View
ENSG00000112655 PTK7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952789 View
ENSG00000137692 DCUN1D5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952767 View
ENSG00000071626 DAZAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952749 View
ENSG00000075945 KIFAP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952646 View
ENSG00000078399 HOXA9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952643 View
ENSG00000132906 CASP9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95263 View
ENSG00000091039 OSBPL8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952552 View
ENSG00000146648 EGFR ENSG00000165806 CASP7 H. sapiens SSL Slorth 0.95255 View
ENSG00000125977 EIF2S2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952536 View
ENSG00000107758 PPP3CB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952486 View
ENSG00000077150 NFKB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952456 View
ENSG00000146648 EGFR ENSG00000154582 TCEB1 H. sapiens SDL Slorth 0.952443 View
ENSG00000140807 NKD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952388 View
ENSG00000146648 EGFR ENSG00000185811 IKZF1 H. sapiens SSL Slorth 0.952357 View
ENSG00000124788 ATXN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952314 View
ENSG00000101210 EEF1A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95222 View
ENSG00000099992 TBC1D10A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95222 View
ENSG00000136286 MYO1G ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95222 View
ENSG00000116761 CTH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95222 View
ENSG00000068796 KIF2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95222 View
ENSG00000069869 NEDD4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952198 View
ENSG00000064419 TNPO3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952187 View
ENSG00000120948 TARDBP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.952173 View
ENSG00000146648 EGFR ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.952088 View
ENSG00000146648 EGFR ENSG00000163743 RCHY1 H. sapiens SSL Slorth 0.952079 View
ENSG00000146648 EGFR ENSG00000198400 NTRK1 H. sapiens SSL Slorth 0.951891 View