EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000038532 CLEC16A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000120694 HSPH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954417 View
ENSG00000146648 EGFR ENSG00000183765 CHEK2 H. sapiens SDL Slorth 0.954361 View
ENSG00000141480 ARRB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954349 View
ENSG00000071537 SEL1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954349 View
ENSG00000146648 EGFR ENSG00000148606 POLR3A H. sapiens SDL Slorth 0.954264 View
ENSG00000146648 EGFR ENSG00000157601 MX1 H. sapiens SDL Slorth 0.954103 View
ENSG00000137764 MAP2K5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954083 View
ENSG00000077549 CAPZB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954077 View
ENSG00000134308 YWHAQ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954014 View
ENSG00000140455 USP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953985 View
ENSG00000127663 KDM4B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000138641 HERC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000075415 SLC25A3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000143653 SCCPDH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000072210 ALDH3A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000145284 SCD5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000141279 NPEPPS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000072682 P4HA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000003989 SLC7A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000106348 IMPDH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953978 View
ENSG00000062822 POLD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953941 View
ENSG00000146648 EGFR ENSG00000165304 MELK H. sapiens SDL Slorth 0.953928 View
ENSG00000117461 PIK3R3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953916 View
ENSG00000108061 SHOC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953916 View
ENSG00000085840 ORC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95389 View
ENSG00000123983 ACSL3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953829 View
ENSG00000143153 ATP1B1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953829 View
ENSG00000146648 EGFR ENSG00000154237 LRRK1 H. sapiens SDL Slorth 0.953807 View
ENSG00000146648 EGFR ENSG00000147403 RPL10 H. sapiens SDL Slorth 0.953725 View
ENSG00000111642 CHD4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9537 View
ENSG00000076108 BAZ2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953695 View
ENSG00000146648 EGFR ENSG00000157020 SEC13 H. sapiens SDL Slorth 0.953679 View
ENSG00000101665 SMAD7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953604 View
ENSG00000146648 EGFR ENSG00000147133 TAF1 H. sapiens SDL Slorth 0.953596 View
ENSG00000146648 EGFR ENSG00000170035 UBE2E3 H. sapiens SSL Slorth 0.953562 View
ENSG00000146648 EGFR ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953548 View
ENSG00000115904 SOS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953482 View
ENSG00000117399 CDC20 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.953471 View
ENSG00000146648 EGFR ENSG00000157404 KIT H. sapiens SSL Slorth 0.953456 View