EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000171793 CTPS1 H. sapiens SDL Slorth 0.955164 View
ENSG00000146648 EGFR ENSG00000148408 CACNA1B H. sapiens SDL Slorth 0.955164 View
ENSG00000146648 EGFR ENSG00000213782 DDX47 H. sapiens SDL Slorth 0.955164 View
ENSG00000146648 EGFR ENSG00000172890 NADSYN1 H. sapiens SDL Slorth 0.955164 View
ENSG00000146648 EGFR ENSG00000159399 HK2 H. sapiens SDL Slorth 0.955164 View
ENSG00000120833 SOCS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955149 View
ENSG00000146648 EGFR ENSG00000160445 ZER1 H. sapiens SDL Slorth 0.955034 View
ENSG00000146648 EGFR ENSG00000205531 NAP1L4 H. sapiens SSL Slorth 0.955011 View
ENSG00000146648 EGFR ENSG00000196419 XRCC6 H. sapiens SDL Slorth 0.95501 View
ENSG00000102241 HTATSF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954992 View
ENSG00000146648 EGFR ENSG00000159259 CHAF1B H. sapiens SSL Slorth 0.954989 View
ENSG00000103126 AXIN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954985 View
ENSG00000146648 EGFR ENSG00000157087 ATP2B2 H. sapiens SDL Slorth 0.95497 View
ENSG00000011405 PIK3C2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954968 View
ENSG00000146648 EGFR ENSG00000167258 CDK12 H. sapiens SDL Slorth 0.95496 View
ENSG00000113140 SPARC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954915 View
ENSG00000126524 SBDS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954861 View
ENSG00000110172 CHORDC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954778 View
ENSG00000146648 EGFR ENSG00000188906 LRRK2 H. sapiens SDL Slorth 0.954768 View
ENSG00000083799 CYLD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954745 View
ENSG00000137693 YAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.954697 View
ENSG00000146648 EGFR ENSG00000198692 EIF1AY H. sapiens SDL Slorth 0.954672 View
ENSG00000126883 NUP214 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95462 View
ENSG00000070961 ATP2B1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95461 View
ENSG00000084733 RAB10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95461 View
ENSG00000085563 ABCB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95461 View
ENSG00000075886 TUBA3D ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000068137 PLEKHH3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000103160 HSDL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000101104 PABPC1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000106066 CPVL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000144909 OSBPL11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000129003 VPS13C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000082213 C5orf22 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000100731 PCNX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000065833 ME1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000132746 ALDH3B2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000137269 LRRC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000101335 MYL9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View
ENSG00000011052 NME1-NME2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95446 View