EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000169139 UBE2V2 H. sapiens SDL Slorth 0.956291 View
ENSG00000146648 EGFR ENSG00000167670 CHAF1A H. sapiens SDL Slorth 0.956261 View
ENSG00000138668 HNRNPD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.956222 View
ENSG00000108370 RGS9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.956204 View
ENSG00000146648 EGFR ENSG00000164885 CDK5 H. sapiens SDL Slorth 0.956115 View
ENSG00000139163 ETNK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95608 View
ENSG00000119787 ATL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95608 View
ENSG00000146648 EGFR ENSG00000151692 RNF144A H. sapiens SDL Slorth 0.956026 View
ENSG00000108443 RPS6KB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.956013 View
ENSG00000035928 RFC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955967 View
ENSG00000133275 CSNK1G2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955965 View
ENSG00000132341 RAN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955907 View
ENSG00000139370 SLC15A4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000116791 CRYZ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000145860 RNF145 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000108828 VAT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000111713 GYS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000143149 ALDH9A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000109814 UGDH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000120733 KDM3B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000140526 ABHD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000069849 ATP1B3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000132463 GRSF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000114374 USP9Y ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955901 View
ENSG00000109606 DHX15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955873 View
ENSG00000146648 EGFR ENSG00000196531 NACA H. sapiens SDL Slorth 0.95587 View
ENSG00000143322 ABL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955865 View
ENSG00000146648 EGFR ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.955864 View
ENSG00000146648 EGFR ENSG00000186111 PIP5K1C H. sapiens SDL Slorth 0.955776 View
ENSG00000110321 EIF4G2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955564 View
ENSG00000146648 EGFR ENSG00000152234 ATP5A1 H. sapiens SDL Slorth 0.955535 View
ENSG00000115902 SLC1A4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955531 View
ENSG00000079215 SLC1A3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955531 View
ENSG00000106462 EZH2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95551 View
ENSG00000029153 ARNTL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955476 View
ENSG00000146648 EGFR ENSG00000185345 PARK2 H. sapiens SDL Slorth 0.955414 View
ENSG00000043591 ADRB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.955342 View
ENSG00000146648 EGFR ENSG00000157823 AP3S2 H. sapiens SDL Slorth 0.955297 View
ENSG00000075624 ACTB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95529 View
ENSG00000019995 ZRANB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95527 View