EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000169372 CRADD H. sapiens SDL Slorth 0.963193 View
ENSG00000146648 EGFR ENSG00000166484 MAPK7 H. sapiens SDL Slorth 0.963128 View
ENSG00000116044 NFE2L2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963105 View
ENSG00000146648 EGFR ENSG00000175793 SFN H. sapiens SSL Slorth 0.963101 View
ENSG00000016082 ISL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963071 View
ENSG00000132141 CCT6B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963028 View
ENSG00000049246 PER3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962958 View
ENSG00000061938 TNK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962922 View
ENSG00000100227 POLDIP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962894 View
ENSG00000137055 PLAA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96287 View
ENSG00000146648 EGFR ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.962857 View
ENSG00000146648 EGFR ENSG00000172269 DPAGT1 H. sapiens SDL Slorth 0.96285 View
ENSG00000146648 EGFR ENSG00000165406 MARCH8 H. sapiens SDL Slorth 0.96285 View
ENSG00000146648 EGFR ENSG00000198589 LRBA H. sapiens SDL Slorth 0.96285 View
ENSG00000146648 EGFR ENSG00000160746 ANO10 H. sapiens SDL Slorth 0.96285 View
ENSG00000132694 ARHGEF11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962849 View
ENSG00000146648 EGFR ENSG00000159216 RUNX1 H. sapiens SSL Slorth 0.962725 View
ENSG00000145242 EPHA5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962708 View
ENSG00000100345 MYH9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962688 View
ENSG00000099940 SNAP29 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962662 View
ENSG00000146648 EGFR ENSG00000198838 RYR3 H. sapiens SDL Slorth 0.962617 View
ENSG00000077522 ACTN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96256 View
ENSG00000146648 EGFR ENSG00000166483 WEE1 H. sapiens SSL Slorth 0.96251 View
ENSG00000115657 ABCB6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962472 View
ENSG00000090776 EFNB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962472 View
ENSG00000071539 TRIP13 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962461 View
ENSG00000064309 CDON ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962408 View
ENSG00000146648 EGFR ENSG00000169398 PTK2 H. sapiens SDL Slorth 0.962399 View
ENSG00000136931 NR5A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962392 View
ENSG00000090273 NUDC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962385 View
ENSG00000146648 EGFR ENSG00000177879 AP3S1 H. sapiens SDL Slorth 0.962247 View
ENSG00000146648 EGFR ENSG00000197442 MAP3K5 H. sapiens SDL Slorth 0.962222 View
ENSG00000146648 EGFR ENSG00000148634 HERC4 H. sapiens SDL Slorth 0.962191 View
ENSG00000146648 EGFR ENSG00000151475 SLC25A31 H. sapiens SDL Slorth 0.962191 View
ENSG00000146648 EGFR ENSG00000149257 SERPINH1 H. sapiens SDL Slorth 0.962191 View
ENSG00000146648 EGFR ENSG00000180957 PITPNB H. sapiens SDL Slorth 0.962191 View
ENSG00000145907 G3BP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962134 View
ENSG00000105397 TYK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962064 View
ENSG00000051382 PIK3CB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962045 View
ENSG00000107954 NEURL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.962038 View