EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000185624 P4HB H. sapiens SDL Slorth 0.962034 View
ENSG00000146648 EGFR ENSG00000175793 SFN H. sapiens SDL Slorth 0.961994 View
ENSG00000128602 SMO ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961983 View
ENSG00000146648 EGFR ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.961968 View
ENSG00000067057 PFKP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961928 View
ENSG00000105409 ATP1A3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961743 View
ENSG00000068366 ACSL4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961743 View
ENSG00000144746 ARL6IP5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961743 View
ENSG00000141127 PRPSAP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961739 View
ENSG00000079332 SAR1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961739 View
ENSG00000139746 RBM26 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961739 View
ENSG00000134644 PUM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961739 View
ENSG00000101608 MYL12A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961739 View
ENSG00000070808 CAMK2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961737 View
ENSG00000092969 TGFB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961715 View
ENSG00000146648 EGFR ENSG00000161202 DVL3 H. sapiens SDL Slorth 0.961706 View
ENSG00000065559 MAP2K4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961676 View
ENSG00000146648 EGFR ENSG00000171148 TADA3 H. sapiens SDL Slorth 0.961672 View
ENSG00000146648 EGFR ENSG00000197153 HIST1H3J H. sapiens SDL Slorth 0.961639 View
ENSG00000146648 EGFR ENSG00000197111 PCBP2 H. sapiens SDL Slorth 0.961587 View
ENSG00000146648 EGFR ENSG00000149136 SSRP1 H. sapiens SDL Slorth 0.961564 View
ENSG00000083544 TDRD3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961561 View
ENSG00000107581 EIF3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961546 View
ENSG00000146648 EGFR ENSG00000147044 CASK H. sapiens SDL Slorth 0.961537 View
ENSG00000108946 PRKAR1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961494 View
ENSG00000146648 EGFR ENSG00000164104 HMGB2 H. sapiens SDL Slorth 0.96144 View
ENSG00000146648 EGFR ENSG00000184009 ACTG1 H. sapiens SDL Slorth 0.96141 View
ENSG00000102010 BMX ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961385 View
ENSG00000146648 EGFR ENSG00000159459 UBR1 H. sapiens SDL Slorth 0.96137 View
ENSG00000064655 EYA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96136 View
ENSG00000137486 ARRB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961353 View
ENSG00000136573 BLK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961351 View
ENSG00000144852 NR1I2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961342 View
ENSG00000134899 ERCC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961332 View
ENSG00000146648 EGFR ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.961297 View
ENSG00000146648 EGFR ENSG00000175390 EIF3F H. sapiens SDL Slorth 0.961269 View
ENSG00000118513 MYB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961265 View
ENSG00000125354 SEPT6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961259 View
ENSG00000079785 DDX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961237 View
ENSG00000146648 EGFR ENSG00000196396 PTPN1 H. sapiens SDL Slorth 0.961236 View