EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000283094 PTEN H. sapiens SDL Slorth 0.961165 View
ENSG00000146648 EGFR ENSG00000147614 ATP6V0D2 H. sapiens SDL Slorth 0.961156 View
ENSG00000146648 EGFR ENSG00000150907 FOXO1 H. sapiens SSL Slorth 0.961147 View
ENSG00000146648 EGFR ENSG00000156970 BUB1B H. sapiens SSL Slorth 0.961119 View
ENSG00000146648 EGFR ENSG00000168385 SEPT2 H. sapiens SDL Slorth 0.961111 View
ENSG00000141503 MINK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961097 View
ENSG00000111711 GOLT1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.961097 View
ENSG00000146648 EGFR ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.960999 View
ENSG00000146648 EGFR ENSG00000168496 FEN1 H. sapiens SSL Slorth 0.960968 View
ENSG00000101199 ARFGAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960948 View
ENSG00000114062 UBE3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960941 View
ENSG00000146648 EGFR ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.960939 View
ENSG00000087086 FTL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960927 View
ENSG00000074370 ATP2A3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000143545 RAB13 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000117143 UAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000075673 ATP12A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000138363 ATIC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000105281 SLC1A5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000035687 ADSS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000074054 CLASP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000137285 TUBB2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000108523 RNF167 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000138138 ATAD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000101152 DNAJC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000139514 SLC7A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000139734 DIAPH3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000124067 SLC12A4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000066279 ASPM ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000102804 TSC22D1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000123131 PRDX4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960899 View
ENSG00000146648 EGFR ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.96088 View
ENSG00000070770 CSNK2A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960865 View
ENSG00000139220 PPFIA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960855 View
ENSG00000146648 EGFR ENSG00000147065 MSN H. sapiens SDL Slorth 0.960853 View
ENSG00000105810 CDK6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960688 View
ENSG00000146648 EGFR ENSG00000166913 YWHAB H. sapiens SDL Slorth 0.960655 View
ENSG00000146648 EGFR ENSG00000157106 SMG1 H. sapiens SSL Slorth 0.960576 View
ENSG00000062650 WAPL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960567 View
ENSG00000146648 EGFR ENSG00000185359 HGS H. sapiens SSL Slorth 0.960539 View