EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000133392 MYH11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959448 View
ENSG00000146648 EGFR ENSG00000147274 RBMX H. sapiens SSL Slorth 0.959445 View
ENSG00000144476 ACKR3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959356 View
ENSG00000116489 CAPZA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959337 View
ENSG00000128872 TMOD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959313 View
ENSG00000146648 EGFR ENSG00000170385 SLC30A1 H. sapiens SDL Slorth 0.959294 View
ENSG00000138175 ARL3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959293 View
ENSG00000072110 ACTN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959274 View
ENSG00000106546 AHR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959233 View
ENSG00000137807 KIF23 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959097 View
ENSG00000137825 ITPKA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959053 View
ENSG00000146648 EGFR ENSG00000173207 CKS1B H. sapiens SDL Slorth 0.958964 View
ENSG00000146648 EGFR ENSG00000165392 WRN H. sapiens SDL Slorth 0.958963 View
ENSG00000106976 DNM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958929 View
ENSG00000146648 EGFR ENSG00000163349 HIPK1 H. sapiens SDL Slorth 0.95891 View
ENSG00000146648 EGFR ENSG00000153487 ING1 H. sapiens SSL Slorth 0.958878 View
ENSG00000117751 PPP1R8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958846 View
ENSG00000089876 DHX32 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958824 View
ENSG00000105357 MYH14 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958824 View
ENSG00000146648 EGFR ENSG00000221823 PPP3R1 H. sapiens SDL Slorth 0.958803 View
ENSG00000121989 ACVR2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958793 View
ENSG00000146648 EGFR ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.958785 View
ENSG00000091106 NLRC4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958666 View
ENSG00000104313 EYA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958617 View
ENSG00000146648 EGFR ENSG00000198793 MTOR H. sapiens SSL Slorth 0.958596 View
ENSG00000146648 EGFR ENSG00000196296 ATP2A1 H. sapiens SDL Slorth 0.958591 View
ENSG00000131238 PPT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958569 View
ENSG00000123338 NCKAP1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958551 View
ENSG00000089280 FUS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95855 View
ENSG00000146648 EGFR ENSG00000177302 TOP3A H. sapiens SDL Slorth 0.958549 View
ENSG00000146648 EGFR ENSG00000215041 NEURL4 H. sapiens SDL Slorth 0.958546 View
ENSG00000146648 EGFR ENSG00000147162 OGT H. sapiens SSL Slorth 0.958484 View
ENSG00000039319 ZFYVE16 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95846 View
ENSG00000100836 PABPN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95846 View
ENSG00000138413 IDH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95846 View
ENSG00000140263 SORD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95846 View
ENSG00000138071 ACTR2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958423 View
ENSG00000074319 TSG101 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958395 View
ENSG00000118007 STAG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.958347 View
ENSG00000146648 EGFR ENSG00000164690 SHH H. sapiens SDL Slorth 0.958316 View