EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000100722 ZC3H14 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965532 View
ENSG00000124380 SNRNP27 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96553 View
ENSG00000101265 RASSF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965471 View
ENSG00000111206 FOXM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965468 View
ENSG00000122592 HOXA7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965317 View
ENSG00000063438 AHRR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965317 View
ENSG00000146648 EGFR ENSG00000170759 KIF5B H. sapiens SDL Slorth 0.965298 View
ENSG00000146648 EGFR ENSG00000151694 ADAM17 H. sapiens SDL Slorth 0.965277 View
ENSG00000146648 EGFR ENSG00000220205 VAMP2 H. sapiens SDL Slorth 0.96527 View
ENSG00000146648 EGFR ENSG00000172315 TP53RK H. sapiens SDL Slorth 0.965198 View
ENSG00000100462 PRMT5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965167 View
ENSG00000078053 AMPH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965163 View
ENSG00000145495 MARCH6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965082 View
ENSG00000100347 SAMM50 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965071 View
ENSG00000066056 TIE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965055 View
ENSG00000047410 TPR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965003 View
ENSG00000146648 EGFR ENSG00000171132 PRKCE H. sapiens SDL Slorth 0.964997 View
ENSG00000146648 EGFR ENSG00000198887 SMC5 H. sapiens SDL Slorth 0.964984 View
ENSG00000146648 EGFR ENSG00000175334 BANF1 H. sapiens SDL Slorth 0.964959 View
ENSG00000128591 FLNC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964947 View
ENSG00000102900 NUP93 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964928 View
ENSG00000128595 CALU ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964916 View
ENSG00000075711 DLG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96488 View
ENSG00000075785 RAB7A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964876 View
ENSG00000146648 EGFR ENSG00000165732 DDX21 H. sapiens SDL Slorth 0.96485 View
ENSG00000143507 DUSP10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964845 View
ENSG00000112697 TMEM30A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96482 View
ENSG00000146648 EGFR ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.964807 View
ENSG00000100281 HMGXB4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964799 View
ENSG00000146648 EGFR ENSG00000178999 AURKB H. sapiens SDL Slorth 0.964757 View
ENSG00000101197 BIRC7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96473 View
ENSG00000107551 RASSF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964722 View
ENSG00000146648 EGFR ENSG00000151532 VTI1A H. sapiens SDL Slorth 0.964684 View
ENSG00000075413 MARK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964668 View
ENSG00000092529 CAPN3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964612 View
ENSG00000078018 MAP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964535 View
ENSG00000134853 PDGFRA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964513 View
ENSG00000144867 SRPRB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964503 View
ENSG00000102554 KLF5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964489 View
ENSG00000146648 EGFR ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.964468 View