EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000042088 TDP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960532 View
ENSG00000122779 TRIM24 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960526 View
ENSG00000083642 PDS5B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960509 View
ENSG00000146648 EGFR ENSG00000162909 CAPN2 H. sapiens SDL Slorth 0.960482 View
ENSG00000146648 EGFR ENSG00000196235 SUPT5H H. sapiens SDL Slorth 0.960464 View
ENSG00000106278 PTPRZ1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960435 View
ENSG00000101213 PTK6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960421 View
ENSG00000077782 FGFR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960245 View
ENSG00000138190 EXOC6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960182 View
ENSG00000130177 CDC16 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96016 View
ENSG00000146648 EGFR ENSG00000163904 SENP2 H. sapiens SDL Slorth 0.960134 View
ENSG00000146648 EGFR ENSG00000197157 SND1 H. sapiens SDL Slorth 0.960103 View
ENSG00000135446 CDK4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.960061 View
ENSG00000146648 EGFR ENSG00000163625 WDFY3 H. sapiens SDL Slorth 0.960052 View
ENSG00000146648 EGFR ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.960021 View
ENSG00000146648 EGFR ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.959988 View
ENSG00000134982 APC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95994 View
ENSG00000144554 FANCD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959911 View
ENSG00000126216 TUBGCP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959911 View
ENSG00000146648 EGFR ENSG00000170027 YWHAG H. sapiens SSL Slorth 0.959869 View
ENSG00000125378 BMP4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959856 View
ENSG00000146648 EGFR ENSG00000213585 VDAC1 H. sapiens SDL Slorth 0.959852 View
ENSG00000113448 PDE4D ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959838 View
ENSG00000146648 EGFR ENSG00000211455 STK38L H. sapiens SDL Slorth 0.959828 View
ENSG00000115310 RTN4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959818 View
ENSG00000125968 ID1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959767 View
ENSG00000146648 EGFR ENSG00000244687 UBE2V1 H. sapiens SSL Slorth 0.959757 View
ENSG00000083520 DIS3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959754 View
ENSG00000146648 EGFR ENSG00000187109 NAP1L1 H. sapiens SSL Slorth 0.959733 View
ENSG00000114573 ATP6V1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959716 View
ENSG00000122218 COPA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.95968 View
ENSG00000119508 NR4A3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959678 View
ENSG00000146648 EGFR ENSG00000149930 TAOK2 H. sapiens SDL Slorth 0.959643 View
ENSG00000146648 EGFR ENSG00000181163 NPM1 H. sapiens SDL Slorth 0.959638 View
ENSG00000114416 FXR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959613 View
ENSG00000146648 EGFR ENSG00000187608 ISG15 H. sapiens SDL Slorth 0.959607 View
ENSG00000139567 ACVRL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959536 View
ENSG00000071127 WDR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959528 View
ENSG00000123836 PFKFB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.959465 View
ENSG00000146648 EGFR ENSG00000184634 MED12 H. sapiens SDL Slorth 0.959455 View