EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000138032 PPM1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966375 View
ENSG00000146648 EGFR ENSG00000205302 SNX2 H. sapiens SDL Slorth 0.966342 View
ENSG00000108654 DDX5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966329 View
ENSG00000124171 PARD6B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966314 View
ENSG00000146648 EGFR ENSG00000168488 ATXN2L H. sapiens SDL Slorth 0.966307 View
ENSG00000138107 ACTR1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966288 View
ENSG00000146648 EGFR ENSG00000167460 TPM4 H. sapiens SDL Slorth 0.966269 View
ENSG00000092853 CLSPN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966228 View
ENSG00000112081 SRSF3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966223 View
ENSG00000130779 CLIP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966205 View
ENSG00000111581 NUP107 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966172 View
ENSG00000079277 MKNK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966156 View
ENSG00000019582 CD74 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966152 View
ENSG00000124535 WRNIP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966147 View
ENSG00000146648 EGFR ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.966123 View
ENSG00000037042 TUBG2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966119 View
ENSG00000128052 KDR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966104 View
ENSG00000138443 ABI2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966067 View
ENSG00000146648 EGFR ENSG00000173473 SMARCC1 H. sapiens SDL Slorth 0.966061 View
ENSG00000146648 EGFR ENSG00000163110 PDLIM5 H. sapiens SDL Slorth 0.966039 View
ENSG00000146648 EGFR ENSG00000185236 RAB11B H. sapiens SDL Slorth 0.966035 View
ENSG00000146648 EGFR ENSG00000175216 CKAP5 H. sapiens SDL Slorth 0.965962 View
ENSG00000146648 EGFR ENSG00000172071 EIF2AK3 H. sapiens SDL Slorth 0.965904 View
ENSG00000126934 MAP2K2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965903 View
ENSG00000096746 HNRNPH3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965898 View
ENSG00000134438 RAX ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965887 View
ENSG00000146648 EGFR ENSG00000163029 SMC6 H. sapiens SDL Slorth 0.965868 View
ENSG00000111348 ARHGDIB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965843 View
ENSG00000146648 EGFR ENSG00000170525 PFKFB3 H. sapiens SDL Slorth 0.965808 View
ENSG00000130956 HABP4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965803 View
ENSG00000121966 CXCR4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965784 View
ENSG00000116039 ATP6V1B1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965733 View
ENSG00000130669 PAK4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965708 View
ENSG00000104320 NBN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965694 View
ENSG00000133794 ARNTL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965633 View
ENSG00000126581 BECN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965624 View
ENSG00000119421 NDUFA8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965605 View
ENSG00000146648 EGFR ENSG00000158402 CDC25C H. sapiens SSL Slorth 0.965579 View
ENSG00000113300 CNOT6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965555 View
ENSG00000104907 TRMT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965532 View