EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000138814 PPP3CA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964461 View
ENSG00000049768 FOXP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96446 View
ENSG00000146648 EGFR ENSG00000180098 TRNAU1AP H. sapiens SDL Slorth 0.964443 View
ENSG00000111737 RAB35 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964429 View
ENSG00000146648 EGFR ENSG00000182208 MOB2 H. sapiens SDL Slorth 0.964413 View
ENSG00000122545 SEPT7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964382 View
ENSG00000104884 ERCC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964369 View
ENSG00000146648 EGFR ENSG00000164327 RICTOR H. sapiens SDL Slorth 0.964351 View
ENSG00000101336 HCK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964316 View
ENSG00000118515 SGK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964295 View
ENSG00000136717 BIN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964289 View
ENSG00000108055 SMC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964286 View
ENSG00000146648 EGFR ENSG00000169710 FASN H. sapiens SDL Slorth 0.96428 View
ENSG00000133124 IRS4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964257 View
ENSG00000146648 EGFR ENSG00000170345 FOS H. sapiens SSL Slorth 0.964197 View
ENSG00000130429 ARPC1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964178 View
ENSG00000146648 EGFR ENSG00000157933 SKI H. sapiens SSL Slorth 0.964162 View
ENSG00000146648 EGFR ENSG00000168214 RBPJ H. sapiens SDL Slorth 0.964139 View
ENSG00000134333 LDHA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96411 View
ENSG00000111716 LDHB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96411 View
ENSG00000108587 GOSR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964088 View
ENSG00000138646 HERC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964085 View
ENSG00000067048 DDX3Y ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964085 View
ENSG00000082153 BZW1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964085 View
ENSG00000136261 BZW2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964085 View
ENSG00000075426 FOSL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964045 View
ENSG00000115677 HDLBP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.964027 View
ENSG00000126602 TRAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963999 View
ENSG00000146648 EGFR ENSG00000172936 MYD88 H. sapiens SDL Slorth 0.963993 View
ENSG00000070404 FSTL3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963979 View
ENSG00000090539 CHRD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963913 View
ENSG00000118217 ATF6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963885 View
ENSG00000115282 TTC31 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963847 View
ENSG00000100038 TOP3B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963828 View
ENSG00000146648 EGFR ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.963825 View
ENSG00000117400 MPL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963824 View
ENSG00000108669 CYTH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963801 View
ENSG00000124491 F13A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963783 View
ENSG00000146648 EGFR ENSG00000161618 ALDH16A1 H. sapiens SDL Slorth 0.963778 View
ENSG00000146648 EGFR ENSG00000151846 PABPC3 H. sapiens SDL Slorth 0.963778 View