EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000183785 TUBA8 H. sapiens SDL Slorth 0.963778 View
ENSG00000146648 EGFR ENSG00000197601 FAR1 H. sapiens SDL Slorth 0.963778 View
ENSG00000146648 EGFR ENSG00000160752 FDPS H. sapiens SDL Slorth 0.963778 View
ENSG00000067225 PKM ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963773 View
ENSG00000146648 EGFR ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.963713 View
ENSG00000131462 TUBG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963675 View
ENSG00000119729 RHOQ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963657 View
ENSG00000107201 DDX58 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963638 View
ENSG00000076356 PLXNA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963612 View
ENSG00000146648 EGFR ENSG00000163399 ATP1A1 H. sapiens SDL Slorth 0.963567 View
ENSG00000146648 EGFR ENSG00000170473 PYM1 H. sapiens SDL Slorth 0.963557 View
ENSG00000122882 ECD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963541 View
ENSG00000146648 EGFR ENSG00000158290 CUL4B H. sapiens SDL Slorth 0.96354 View
ENSG00000076984 MAP2K7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963534 View
ENSG00000076344 RGS11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963531 View
ENSG00000101367 MAPRE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96353 View
ENSG00000146648 EGFR ENSG00000205250 E2F4 H. sapiens SDL Slorth 0.963525 View
ENSG00000124164 VAPB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963517 View
ENSG00000120075 HOXB5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963517 View
ENSG00000146648 EGFR ENSG00000172725 CORO1B H. sapiens SDL Slorth 0.963514 View
ENSG00000121067 SPOP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963477 View
ENSG00000039068 CDH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963466 View
ENSG00000146648 EGFR ENSG00000283094 PTEN H. sapiens SSL Slorth 0.963454 View
ENSG00000136877 FPGS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000132681 ATP1A4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000120756 PLS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000135924 DNAJB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000091127 PUS7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000079739 PGM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000101337 TM9SF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000113504 SLC12A7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000139190 VAMP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000109220 CHIC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000091483 FH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96345 View
ENSG00000087095 NLK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963445 View
ENSG00000054118 THRAP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963383 View
ENSG00000146648 EGFR ENSG00000188906 LRRK2 H. sapiens SSL Slorth 0.963345 View
ENSG00000146648 EGFR ENSG00000152818 UTRN H. sapiens SDL Slorth 0.963314 View
ENSG00000111199 TRPV4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963257 View
ENSG00000143257 NR1I3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.963196 View