EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000064489 BORCS8-MEF2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967095 View
ENSG00000121892 PDS5A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967086 View
ENSG00000146648 EGFR ENSG00000160285 LSS H. sapiens SDL Slorth 0.967067 View
ENSG00000066136 NFYC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967051 View
ENSG00000146648 EGFR ENSG00000197879 MYO1C H. sapiens SDL Slorth 0.96703 View
ENSG00000146648 EGFR ENSG00000151276 MAGI1 H. sapiens SDL Slorth 0.967017 View
ENSG00000146648 EGFR ENSG00000186868 MAPT H. sapiens SDL Slorth 0.966998 View
ENSG00000101911 PRPS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966993 View
ENSG00000137309 HMGA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966989 View
ENSG00000037280 FLT4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966959 View
ENSG00000146648 EGFR ENSG00000171456 ASXL1 H. sapiens SDL Slorth 0.966941 View
ENSG00000089685 BIRC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966926 View
ENSG00000138757 G3BP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966923 View
ENSG00000105486 LIG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966921 View
ENSG00000146648 EGFR ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.966854 View
ENSG00000146648 EGFR ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.966829 View
ENSG00000109819 PPARGC1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96682 View
ENSG00000112742 TTK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966816 View
ENSG00000117450 PRDX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966787 View
ENSG00000116833 NR5A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966747 View
ENSG00000146648 EGFR ENSG00000170004 CHD3 H. sapiens SDL Slorth 0.966715 View
ENSG00000143384 MCL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966712 View
ENSG00000141551 CSNK1D ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966701 View
ENSG00000092820 EZR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966691 View
ENSG00000048462 TNFRSF17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966659 View
ENSG00000109756 RAPGEF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966654 View
ENSG00000069424 KCNAB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966562 View
ENSG00000134684 YARS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966554 View
ENSG00000020633 RUNX3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966513 View
ENSG00000100968 NFATC4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966495 View
ENSG00000146648 EGFR ENSG00000168496 FEN1 H. sapiens SDL Slorth 0.966488 View
ENSG00000115884 SDC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966485 View
ENSG00000112079 STK38 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966463 View
ENSG00000146648 EGFR ENSG00000149554 CHEK1 H. sapiens SSL Slorth 0.966427 View
ENSG00000120705 ETF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966425 View
ENSG00000101558 VAPA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966418 View
ENSG00000130414 NDUFA10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966409 View
ENSG00000127481 UBR4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966408 View
ENSG00000133104 SPG20 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966408 View
ENSG00000125450 NUP85 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.966389 View