EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000137845 ADAM10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967762 View
ENSG00000146648 EGFR ENSG00000150991 UBC H. sapiens SDL Slorth 0.967725 View
ENSG00000041982 TNC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967708 View
ENSG00000134363 FST ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967679 View
ENSG00000108559 NUP88 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967677 View
ENSG00000105402 NAPA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967667 View
ENSG00000146648 EGFR ENSG00000170348 TMED10 H. sapiens SDL Slorth 0.967655 View
ENSG00000135486 HNRNPA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967654 View
ENSG00000025800 KPNA6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967614 View
ENSG00000146648 EGFR ENSG00000198793 MTOR H. sapiens SDL Slorth 0.967603 View
ENSG00000115020 PIKFYVE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967585 View
ENSG00000104964 AES ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967583 View
ENSG00000146648 EGFR ENSG00000177054 ZDHHC13 H. sapiens SDL Slorth 0.96758 View
ENSG00000118971 CCND2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967555 View
ENSG00000132254 ARFIP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967542 View
ENSG00000146648 EGFR ENSG00000148341 SH3GLB2 H. sapiens SDL Slorth 0.967527 View
ENSG00000128340 RAC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967517 View
ENSG00000146648 EGFR ENSG00000198925 ATG9A H. sapiens SDL Slorth 0.967513 View
ENSG00000010017 RANBP9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967513 View
ENSG00000136826 KLF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967439 View
ENSG00000066032 CTNNA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967434 View
ENSG00000049759 NEDD4L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967418 View
ENSG00000146648 EGFR ENSG00000276618 RAD17 H. sapiens SDL Slorth 0.967393 View
ENSG00000146648 EGFR ENSG00000189403 HMGB1 H. sapiens SDL Slorth 0.967383 View
ENSG00000116731 PRDM2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967326 View
ENSG00000114125 RNF7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967315 View
ENSG00000105996 HOXA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967298 View
ENSG00000117650 NEK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967293 View
ENSG00000146648 EGFR ENSG00000147416 ATP6V1B2 H. sapiens SDL Slorth 0.967285 View
ENSG00000080224 EPHA6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967257 View
ENSG00000129691 ASH2L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967257 View
ENSG00000111450 STX2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96721 View
ENSG00000064703 DDX20 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967185 View
ENSG00000113712 CSNK1A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967171 View
ENSG00000111725 PRKAB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967129 View
ENSG00000135100 HNF1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967126 View
ENSG00000142945 KIF2C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967117 View
ENSG00000110880 CORO1C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967117 View
ENSG00000125818 PSMF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.967117 View
ENSG00000146648 EGFR ENSG00000164109 MAD2L1 H. sapiens SDL Slorth 0.967116 View