EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000196591 HDAC2 H. sapiens SDL Slorth 0.926213 View
ENSG00000146648 EGFR ENSG00000198356 ASNA1 H. sapiens SSL Slorth 0.92611 View
ENSG00000146648 EGFR ENSG00000170248 PDCD6IP H. sapiens SSL Slorth 0.925756 View
ENSG00000124486 USP9X ENSG00000146648 EGFR H. sapiens SDL Slorth 0.925665 View
ENSG00000146648 EGFR ENSG00000213585 VDAC1 H. sapiens SSL Slorth 0.925591 View
ENSG00000146648 EGFR ENSG00000168685 IL7R H. sapiens SDL Slorth 0.925553 View
ENSG00000146648 EGFR ENSG00000187735 TCEA1 H. sapiens SSL Slorth 0.925525 View
ENSG00000146648 EGFR ENSG00000164867 NOS3 H. sapiens SSL Slorth 0.925433 View
ENSG00000146648 EGFR ENSG00000168439 STIP1 H. sapiens SSL Slorth 0.925113 View
ENSG00000146648 EGFR ENSG00000167491 GATAD2A H. sapiens SSL Slorth 0.925087 View
ENSG00000141384 TAF4B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.925022 View
ENSG00000146648 EGFR ENSG00000184481 FOXO4 H. sapiens SSL Slorth 0.924972 View
ENSG00000146648 EGFR ENSG00000165115 KIF27 H. sapiens SDL Slorth 0.924921 View
ENSG00000146648 EGFR ENSG00000163629 PTPN13 H. sapiens SSL Slorth 0.924823 View
ENSG00000131759 RARA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.924775 View
ENSG00000136045 PWP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.924645 View
ENSG00000146648 EGFR ENSG00000172757 CFL1 H. sapiens SSL Slorth 0.924585 View
ENSG00000116478 HDAC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.924542 View
ENSG00000146648 EGFR ENSG00000205726 ITSN1 H. sapiens SSL Slorth 0.924284 View
ENSG00000146648 EGFR ENSG00000173757 STAT5B H. sapiens SSL Slorth 0.924265 View
ENSG00000146648 EGFR ENSG00000168872 DDX19A H. sapiens SSL Slorth 0.924264 View
ENSG00000079134 THOC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.924195 View
ENSG00000146648 EGFR ENSG00000196628 TCF4 H. sapiens SSL Slorth 0.924149 View
ENSG00000146648 EGFR ENSG00000149136 SSRP1 H. sapiens SSL Slorth 0.924111 View
ENSG00000104812 GYS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.924097 View
ENSG00000146648 EGFR ENSG00000166747 AP1G1 H. sapiens SSL Slorth 0.924 View
ENSG00000146648 EGFR ENSG00000198909 MAP3K3 H. sapiens SSL Slorth 0.923982 View
ENSG00000103363 TCEB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923911 View
ENSG00000146648 EGFR ENSG00000150593 PDCD4 H. sapiens SSL Slorth 0.923851 View
ENSG00000146648 EGFR ENSG00000182979 MTA1 H. sapiens SSL Slorth 0.923705 View
ENSG00000092621 PHGDH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923671 View
ENSG00000124214 STAU1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923656 View
ENSG00000136279 DBNL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923643 View
ENSG00000146648 EGFR ENSG00000166949 SMAD3 H. sapiens SDL Slorth 0.923456 View
ENSG00000146648 EGFR ENSG00000166407 LMO1 H. sapiens SDL Slorth 0.923424 View
ENSG00000102572 STK24 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923189 View
ENSG00000100297 MCM5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923171 View
ENSG00000124181 PLCG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923137 View
ENSG00000129993 CBFA2T3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.923085 View
ENSG00000146648 EGFR ENSG00000167965 MLST8 H. sapiens SSL Slorth 0.923008 View