EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000105325 FZR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.931471 View
ENSG00000026103 FAS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.931403 View
ENSG00000146648 EGFR ENSG00000150401 DCUN1D2 H. sapiens SDL Slorth 0.931374 View
ENSG00000146648 EGFR ENSG00000174405 LIG4 H. sapiens SSL Slorth 0.931328 View
ENSG00000146648 EGFR ENSG00000166200 COPS2 H. sapiens SSL Slorth 0.931201 View
ENSG00000104852 SNRNP70 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.93107 View
ENSG00000146648 EGFR ENSG00000150672 DLG2 H. sapiens SDL Slorth 0.931061 View
ENSG00000146648 EGFR ENSG00000196923 PDLIM7 H. sapiens SSL Slorth 0.931033 View
ENSG00000067606 PRKCZ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.931025 View
ENSG00000102882 MAPK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930928 View
ENSG00000146648 EGFR ENSG00000158828 PINK1 H. sapiens SSL Slorth 0.930881 View
ENSG00000019549 SNAI2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930833 View
ENSG00000006715 VPS41 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930718 View
ENSG00000146648 EGFR ENSG00000149311 ATM H. sapiens SDL Slorth 0.930646 View
ENSG00000124813 RUNX2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930562 View
ENSG00000146648 EGFR ENSG00000175054 ATR H. sapiens SDL Slorth 0.930507 View
ENSG00000146648 EGFR ENSG00000254995 STX16-NPEPL1 H. sapiens SDL Slorth 0.930472 View
ENSG00000082014 SMARCD3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.93044 View
ENSG00000146648 EGFR ENSG00000153561 RMND5A H. sapiens SDL Slorth 0.930399 View
ENSG00000146648 EGFR ENSG00000148908 RGS10 H. sapiens SDL Slorth 0.930392 View
ENSG00000146648 EGFR ENSG00000173327 MAP3K11 H. sapiens SSL Slorth 0.93023 View
ENSG00000143995 MEIS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930215 View
ENSG00000122367 LDB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930199 View
ENSG00000111602 TIMELESS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930183 View
ENSG00000079387 SENP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930129 View
ENSG00000109534 GAR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930091 View
ENSG00000146648 EGFR ENSG00000164418 GRIK2 H. sapiens SDL Slorth 0.930075 View
ENSG00000033627 ATP6V0A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930075 View
ENSG00000109062 SLC9A3R1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930057 View
ENSG00000143761 ARF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.930001 View
ENSG00000136238 RAC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929996 View
ENSG00000146648 EGFR ENSG00000197157 SND1 H. sapiens SSL Slorth 0.929808 View
ENSG00000146648 EGFR ENSG00000177084 POLE H. sapiens SSL Slorth 0.929798 View
ENSG00000068654 POLR1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929722 View
ENSG00000067560 RHOA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929683 View
ENSG00000146648 EGFR ENSG00000182511 FES H. sapiens SDL Slorth 0.929478 View
ENSG00000004897 CDC27 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929461 View
ENSG00000138081 FBXO11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929458 View
ENSG00000146648 EGFR ENSG00000204435 CSNK2B H. sapiens SDL Slorth 0.929446 View
ENSG00000146648 EGFR ENSG00000164022 AIMP1 H. sapiens SSL Slorth 0.92916 View