EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131023 LATS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929113 View
ENSG00000146648 EGFR ENSG00000196961 AP2A1 H. sapiens SSL Slorth 0.929087 View
ENSG00000146648 EGFR ENSG00000175643 RMI2 H. sapiens SDL Slorth 0.929046 View
ENSG00000101945 SUV39H1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.929042 View
ENSG00000146648 EGFR ENSG00000159216 RUNX1 H. sapiens SDL Slorth 0.928997 View
ENSG00000127445 PIN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.92877 View
ENSG00000146648 EGFR ENSG00000164134 NAA15 H. sapiens SSL Slorth 0.928509 View
ENSG00000146648 EGFR ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.92841 View
ENSG00000104885 DOT1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.928407 View
ENSG00000134480 CCNH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.928355 View
ENSG00000146648 EGFR ENSG00000162409 PRKAA2 H. sapiens SSL Slorth 0.928354 View
ENSG00000146648 EGFR ENSG00000149182 ARFGAP2 H. sapiens SDL Slorth 0.928335 View
ENSG00000133627 ACTR3B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.928333 View
ENSG00000146648 EGFR ENSG00000184009 ACTG1 H. sapiens SSL Slorth 0.928294 View
ENSG00000146648 EGFR ENSG00000166900 STX3 H. sapiens SSL Slorth 0.928113 View
ENSG00000146648 EGFR ENSG00000175203 DCTN2 H. sapiens SSL Slorth 0.928058 View
ENSG00000129152 MYOD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.928036 View
ENSG00000078142 PIK3C3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.928019 View
ENSG00000146648 EGFR ENSG00000184349 EFNA5 H. sapiens SDL Slorth 0.928015 View
ENSG00000146648 EGFR ENSG00000171960 PPIH H. sapiens SSL Slorth 0.927942 View
ENSG00000113194 FAF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927867 View
ENSG00000117118 SDHB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927709 View
ENSG00000096384 HSP90AB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927704 View
ENSG00000108604 SMARCD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927659 View
ENSG00000116560 SFPQ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927649 View
ENSG00000135341 MAP3K7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927575 View
ENSG00000146648 EGFR ENSG00000197579 TOPORS H. sapiens SSL Slorth 0.927461 View
ENSG00000115694 STK25 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927406 View
ENSG00000101868 POLA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.927313 View
ENSG00000146648 EGFR ENSG00000197063 MAFG H. sapiens SDL Slorth 0.927225 View
ENSG00000146648 EGFR ENSG00000183431 SF3A3 H. sapiens SDL Slorth 0.926964 View
ENSG00000125870 SNRPB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.926667 View
ENSG00000146648 EGFR ENSG00000187555 USP7 H. sapiens SSL Slorth 0.926616 View
ENSG00000146648 EGFR ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.926575 View
ENSG00000146648 EGFR ENSG00000213923 CSNK1E H. sapiens SDL Slorth 0.926571 View
ENSG00000146648 EGFR ENSG00000182621 PLCB1 H. sapiens SDL Slorth 0.926475 View
ENSG00000146648 EGFR ENSG00000170836 PPM1D H. sapiens SDL Slorth 0.926397 View
ENSG00000117425 PTCH2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.926394 View
ENSG00000146648 EGFR ENSG00000166794 PPIB H. sapiens SSL Slorth 0.926365 View
ENSG00000146648 EGFR ENSG00000159461 AMFR H. sapiens SSL Slorth 0.92632 View