EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000135476 ESPL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968876 View
ENSG00000008128 CDK11A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968873 View
ENSG00000072274 TFRC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968852 View
ENSG00000021826 CPS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968845 View
ENSG00000089159 PXN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968829 View
ENSG00000126803 HSPA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968828 View
ENSG00000146648 EGFR ENSG00000164466 SFXN1 H. sapiens SDL Slorth 0.968825 View
ENSG00000119535 CSF3R ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96882 View
ENSG00000146648 EGFR ENSG00000197102 DYNC1H1 H. sapiens SDL Slorth 0.968808 View
ENSG00000128059 PPAT ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968796 View
ENSG00000143970 ASXL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968796 View
ENSG00000146535 GNA12 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968783 View
ENSG00000115085 ZAP70 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968779 View
ENSG00000124222 STX16 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968768 View
ENSG00000111540 RAB5B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968762 View
ENSG00000125971 DYNLRB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96873 View
ENSG00000105221 AKT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968663 View
ENSG00000038382 TRIO ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968657 View
ENSG00000130479 MAP1S ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96861 View
ENSG00000138758 SEPT11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96858 View
ENSG00000100401 RANGAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96856 View
ENSG00000146648 EGFR ENSG00000164070 HSPA4L H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000198265 HELZ H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000198492 YTHDF2 H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000166128 RAB8B H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000163017 ACTG2 H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000162616 DNAJB4 H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000157954 WIPI2 H. sapiens SDL Slorth 0.968492 View
ENSG00000146648 EGFR ENSG00000182220 ATP6AP2 H. sapiens SDL Slorth 0.968492 View
ENSG00000143878 RHOB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968476 View
ENSG00000146648 EGFR ENSG00000188042 ARL4C H. sapiens SDL Slorth 0.968443 View
ENSG00000146648 EGFR ENSG00000149187 CELF1 H. sapiens SDL Slorth 0.968443 View
ENSG00000146648 EGFR ENSG00000178035 IMPDH2 H. sapiens SDL Slorth 0.968443 View
ENSG00000069329 VPS35 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968432 View
ENSG00000066044 ELAVL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968429 View
ENSG00000140682 TGFB1I1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968421 View
ENSG00000081721 DUSP12 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968407 View
ENSG00000133895 MEN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968401 View
ENSG00000146648 EGFR ENSG00000174672 BRSK2 H. sapiens SDL Slorth 0.9684 View
ENSG00000146648 EGFR ENSG00000182944 EWSR1 H. sapiens SDL Slorth 0.9684 View