EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000137193 PIM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969401 View
ENSG00000145703 IQGAP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969399 View
ENSG00000146648 EGFR ENSG00000161960 EIF4A1 H. sapiens SDL Slorth 0.969334 View
ENSG00000108469 RECQL5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969313 View
ENSG00000146648 EGFR ENSG00000163513 TGFBR2 H. sapiens SDL Slorth 0.969302 View
ENSG00000134138 MEIS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9693 View
ENSG00000122958 VPS26A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969272 View
ENSG00000130402 ACTN4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969259 View
ENSG00000005961 ITGA2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969221 View
ENSG00000146648 EGFR ENSG00000165801 ARHGEF40 H. sapiens SDL Slorth 0.969184 View
ENSG00000107187 LHX3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969173 View
ENSG00000139318 DUSP6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969169 View
ENSG00000146648 EGFR ENSG00000185532 PRKG1 H. sapiens SDL Slorth 0.969167 View
ENSG00000110047 EHD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969167 View
ENSG00000146648 EGFR ENSG00000157456 CCNB2 H. sapiens SDL Slorth 0.969152 View
ENSG00000143390 RFX5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969147 View
ENSG00000103197 TSC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969142 View
ENSG00000034677 RNF19A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969139 View
ENSG00000044574 HSPA5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969132 View
ENSG00000136944 LMX1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969121 View
ENSG00000144381 HSPD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969106 View
ENSG00000094631 HDAC6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969106 View
ENSG00000066135 KDM4A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969089 View
ENSG00000090432 MUL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969089 View
ENSG00000074181 NOTCH3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969072 View
ENSG00000081059 TCF7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969067 View
ENSG00000146648 EGFR ENSG00000167325 RRM1 H. sapiens SDL Slorth 0.96905 View
ENSG00000086065 CHMP5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969041 View
ENSG00000146648 EGFR ENSG00000177688 SUMO4 H. sapiens SDL Slorth 0.969017 View
ENSG00000113013 HSPA9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969004 View
ENSG00000104856 RELB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968998 View
ENSG00000145506 NKD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968995 View
ENSG00000146648 EGFR ENSG00000164116 GUCY1A3 H. sapiens SDL Slorth 0.968986 View
ENSG00000146648 EGFR ENSG00000204217 BMPR2 H. sapiens SDL Slorth 0.968981 View
ENSG00000110330 BIRC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96898 View
ENSG00000082458 DLG3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968948 View
ENSG00000099783 HNRNPM ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968912 View
ENSG00000070778 PTPN21 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968901 View
ENSG00000123136 DDX39A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.968894 View
ENSG00000114315 HES1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96889 View