EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000165731 RET H. sapiens SDL Slorth 0.969924 View
ENSG00000146648 EGFR ENSG00000177613 CSTF2T H. sapiens SDL Slorth 0.969889 View
ENSG00000141448 GATA6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969866 View
ENSG00000087263 OGFOD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969862 View
ENSG00000146648 EGFR ENSG00000147573 TRIM55 H. sapiens SDL Slorth 0.96985 View
ENSG00000126070 AGO3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969839 View
ENSG00000134070 IRAK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969826 View
ENSG00000108984 MAP2K6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969823 View
ENSG00000146648 EGFR ENSG00000167552 TUBA1A H. sapiens SDL Slorth 0.969813 View
ENSG00000065243 PKN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969808 View
ENSG00000146648 EGFR ENSG00000176102 CSTF3 H. sapiens SDL Slorth 0.969795 View
ENSG00000142733 MAP3K6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969795 View
ENSG00000129911 KLF16 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969766 View
ENSG00000058262 SEC61A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969762 View
ENSG00000137841 PLCB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969732 View
ENSG00000129219 PLD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969707 View
ENSG00000146648 EGFR ENSG00000198648 STK39 H. sapiens SDL Slorth 0.969693 View
ENSG00000146648 EGFR ENSG00000198668 CALM1 H. sapiens SDL Slorth 0.969687 View
ENSG00000115507 OTX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969642 View
ENSG00000143355 LHX9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969642 View
ENSG00000141367 CLTC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969636 View
ENSG00000146648 EGFR ENSG00000196586 MYO6 H. sapiens SDL Slorth 0.96963 View
ENSG00000142875 PRKACB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96962 View
ENSG00000146648 EGFR ENSG00000183570 PCBP3 H. sapiens SDL Slorth 0.969604 View
ENSG00000146648 EGFR ENSG00000168806 LCMT2 H. sapiens SDL Slorth 0.969604 View
ENSG00000146648 EGFR ENSG00000173218 VANGL1 H. sapiens SDL Slorth 0.969604 View
ENSG00000146648 EGFR ENSG00000148834 GSTO1 H. sapiens SDL Slorth 0.969604 View
ENSG00000146648 EGFR ENSG00000188641 DPYD H. sapiens SDL Slorth 0.969604 View
ENSG00000146648 EGFR ENSG00000198218 QRICH1 H. sapiens SDL Slorth 0.969604 View
ENSG00000146648 EGFR ENSG00000189241 TSPYL1 H. sapiens SDL Slorth 0.969604 View
ENSG00000100749 VRK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969599 View
ENSG00000146648 EGFR ENSG00000151247 EIF4E H. sapiens SDL Slorth 0.969586 View
ENSG00000106327 TFR2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969564 View
ENSG00000085733 CTTN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969556 View
ENSG00000135312 HTR1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969548 View
ENSG00000116141 MARK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969532 View
ENSG00000136504 KAT7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969433 View
ENSG00000114650 SCAP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96943 View
ENSG00000141510 TP53 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969413 View
ENSG00000146648 EGFR ENSG00000183856 IQGAP3 H. sapiens SDL Slorth 0.969405 View