EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000137843 PAK6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971473 View
ENSG00000100888 CHD8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971458 View
ENSG00000130787 HIP1R ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97139 View
ENSG00000146648 EGFR ENSG00000150459 SAP18 H. sapiens SDL Slorth 0.971367 View
ENSG00000107263 RAPGEF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97134 View
ENSG00000146648 EGFR ENSG00000162733 DDR2 H. sapiens SDL Slorth 0.971295 View
ENSG00000126778 SIX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971289 View
ENSG00000146648 EGFR ENSG00000198087 CD2AP H. sapiens SDL Slorth 0.971263 View
ENSG00000146648 EGFR ENSG00000156970 BUB1B H. sapiens SDL Slorth 0.971236 View
ENSG00000146648 EGFR ENSG00000168148 HIST3H3 H. sapiens SDL Slorth 0.97122 View
ENSG00000122692 SMU1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971213 View
ENSG00000119912 IDE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971204 View
ENSG00000146648 EGFR ENSG00000174775 HRAS H. sapiens SDL Slorth 0.971194 View
ENSG00000146648 EGFR ENSG00000152601 MBNL1 H. sapiens SDL Slorth 0.971158 View
ENSG00000138795 LEF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97113 View
ENSG00000013375 PGM3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971085 View
ENSG00000103966 EHD4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971072 View
ENSG00000146223 RPL7L1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971061 View
ENSG00000130396 AFDN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971018 View
ENSG00000113282 CLINT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971008 View
ENSG00000087274 ADD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971005 View
ENSG00000146648 EGFR ENSG00000163558 PRKCI H. sapiens SDL Slorth 0.970984 View
ENSG00000114861 FOXP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970979 View
ENSG00000076944 STXBP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970933 View
ENSG00000089250 NOS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97093 View
ENSG00000123159 GIPC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970923 View
ENSG00000138160 KIF11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970919 View
ENSG00000012504 NR1H4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970915 View
ENSG00000146648 EGFR ENSG00000170312 CDK1 H. sapiens SDL Slorth 0.970906 View
ENSG00000143751 SDE2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970868 View
ENSG00000005893 LAMP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970868 View
ENSG00000146648 EGFR ENSG00000198586 TLK1 H. sapiens SDL Slorth 0.970798 View
ENSG00000143258 USP21 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970792 View
ENSG00000145349 CAMK2D ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970767 View
ENSG00000140575 IQGAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970757 View
ENSG00000141867 BRD4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970747 View
ENSG00000099622 CIRBP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97073 View
ENSG00000102145 GATA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97071 View
ENSG00000118046 STK11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970699 View
ENSG00000136273 HUS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970688 View