EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000100596 SPTLC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970664 View
ENSG00000125266 EFNB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97066 View
ENSG00000127527 EPS15L1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970656 View
ENSG00000131711 MAP1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970577 View
ENSG00000068971 PPP2R5B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970551 View
ENSG00000133026 MYH10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970545 View
ENSG00000146648 EGFR ENSG00000163482 STK36 H. sapiens SDL Slorth 0.970521 View
ENSG00000107854 TNKS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970512 View
ENSG00000146648 EGFR ENSG00000159082 SYNJ1 H. sapiens SDL Slorth 0.970506 View
ENSG00000010818 HIVEP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9705 View
ENSG00000131236 CAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9705 View
ENSG00000140299 BNIP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970496 View
ENSG00000130037 KCNA5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970487 View
ENSG00000146648 EGFR ENSG00000196262 PPIA H. sapiens SDL Slorth 0.97048 View
ENSG00000144118 RALB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970472 View
ENSG00000146648 EGFR ENSG00000180370 PAK2 H. sapiens SDL Slorth 0.97047 View
ENSG00000146648 EGFR ENSG00000171621 SPSB1 H. sapiens SDL Slorth 0.970469 View
ENSG00000122566 HNRNPA2B1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970466 View
ENSG00000110422 HIPK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970444 View
ENSG00000145147 SLIT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970443 View
ENSG00000055118 KCNH2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97042 View
ENSG00000126267 COX6B1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970354 View
ENSG00000134375 TIMM17A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970341 View
ENSG00000112339 HBS1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970339 View
ENSG00000004975 DVL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970303 View
ENSG00000143256 PFDN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970286 View
ENSG00000100412 ACO2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970282 View
ENSG00000146648 EGFR ENSG00000189067 LITAF H. sapiens SDL Slorth 0.970262 View
ENSG00000146648 EGFR ENSG00000150457 LATS2 H. sapiens SDL Slorth 0.970244 View
ENSG00000008196 TFAP2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970224 View
ENSG00000129521 EGLN3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97019 View
ENSG00000146648 EGFR ENSG00000167513 CDT1 H. sapiens SDL Slorth 0.970173 View
ENSG00000140750 ARHGAP17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970121 View
ENSG00000101421 CHMP4B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970078 View
ENSG00000146648 EGFR ENSG00000178950 GAK H. sapiens SDL Slorth 0.970035 View
ENSG00000062485 CS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.970009 View
ENSG00000146648 EGFR ENSG00000169083 AR H. sapiens SDL Slorth 0.970001 View
ENSG00000127463 EMC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969995 View
ENSG00000136888 ATP6V1G1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.969981 View
ENSG00000132470 ITGB4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.96994 View