EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000034152 MAP2K3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972157 View
ENSG00000087470 DNM1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972119 View
ENSG00000140443 IGF1R ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972104 View
ENSG00000141738 GRB7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972099 View
ENSG00000132356 PRKAA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97209 View
ENSG00000116120 FARSB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97207 View
ENSG00000131507 NDFIP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972042 View
ENSG00000146648 EGFR ENSG00000150093 ITGB1 H. sapiens SDL Slorth 0.972017 View
ENSG00000146648 EGFR ENSG00000152256 PDK1 H. sapiens SDL Slorth 0.972014 View
ENSG00000100721 TCL1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972012 View
ENSG00000146648 EGFR ENSG00000197323 TRIM33 H. sapiens SDL Slorth 0.971976 View
ENSG00000071051 NCK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971953 View
ENSG00000090061 CCNK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971914 View
ENSG00000139083 ETV6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971895 View
ENSG00000007171 NOS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97189 View
ENSG00000076604 TRAF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971875 View
ENSG00000124145 SDC4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971872 View
ENSG00000087510 TFAP2C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97187 View
ENSG00000090060 PAPOLA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971866 View
ENSG00000119392 GLE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971863 View
ENSG00000146648 EGFR ENSG00000168374 ARF4 H. sapiens SDL Slorth 0.971845 View
ENSG00000126458 RRAS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971801 View
ENSG00000104936 DMPK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97178 View
ENSG00000106803 SEC61B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971751 View
ENSG00000122025 FLT3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971746 View
ENSG00000090376 IRAK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971739 View
ENSG00000085832 EPS15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971721 View
ENSG00000135605 TEC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97172 View
ENSG00000107036 RIC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971704 View
ENSG00000140564 FURIN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97168 View
ENSG00000115355 CCDC88A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971651 View
ENSG00000100591 AHSA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971636 View
ENSG00000110075 PPP6R3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971627 View
ENSG00000111262 KCNA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971614 View
ENSG00000005249 PRKAR2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971595 View
ENSG00000131459 GFPT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971566 View
ENSG00000023445 BIRC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971546 View
ENSG00000072958 AP1M1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971538 View
ENSG00000125503 PPP1R12C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971503 View
ENSG00000092421 SEMA6A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.971497 View