EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000136827 TOR1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972987 View
ENSG00000146648 EGFR ENSG00000213024 NUP62 H. sapiens SDL Slorth 0.972987 View
ENSG00000082258 CCNT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972957 View
ENSG00000146648 EGFR ENSG00000157554 ERG H. sapiens SDL Slorth 0.972953 View
ENSG00000131773 KHDRBS3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972945 View
ENSG00000146648 EGFR ENSG00000167461 RAB8A H. sapiens SDL Slorth 0.972908 View
ENSG00000106615 RHEB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972887 View
ENSG00000102471 NDFIP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972861 View
ENSG00000146648 EGFR ENSG00000179218 CALR H. sapiens SDL Slorth 0.972859 View
ENSG00000088256 GNA11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972858 View
ENSG00000146648 EGFR ENSG00000166974 MAPRE2 H. sapiens SDL Slorth 0.972803 View
ENSG00000146648 EGFR ENSG00000198400 NTRK1 H. sapiens SDL Slorth 0.972781 View
ENSG00000138685 FGF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972752 View
ENSG00000142168 SOD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97274 View
ENSG00000135363 LMO2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972716 View
ENSG00000025434 NR1H3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972713 View
ENSG00000146648 EGFR ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.972701 View
ENSG00000146648 EGFR ENSG00000167986 DDB1 H. sapiens SDL Slorth 0.972694 View
ENSG00000128512 DOCK4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972648 View
ENSG00000013441 CLK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972634 View
ENSG00000065526 SPEN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972593 View
ENSG00000132361 CLUH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972534 View
ENSG00000141985 SH3GL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972527 View
ENSG00000106211 HSPB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972503 View
ENSG00000144857 BOC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972441 View
ENSG00000123124 WWP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97242 View
ENSG00000099246 RAB18 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972395 View
ENSG00000058272 PPP1R12A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972379 View
ENSG00000136754 ABI1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972372 View
ENSG00000146648 EGFR ENSG00000174437 ATP2A2 H. sapiens SDL Slorth 0.972366 View
ENSG00000135144 DTX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972347 View
ENSG00000101132 PFDN4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972344 View
ENSG00000093000 NUP50 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97229 View
ENSG00000007968 E2F2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972278 View
ENSG00000125810 CD93 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97223 View
ENSG00000100307 CBX7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972225 View
ENSG00000146648 EGFR ENSG00000213639 PPP1CB H. sapiens SDL Slorth 0.97219 View
ENSG00000146648 EGFR ENSG00000170296 GABARAP H. sapiens SDL Slorth 0.972188 View
ENSG00000138778 CENPE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.972174 View
ENSG00000146648 EGFR ENSG00000176014 TUBB6 H. sapiens SDL Slorth 0.972174 View