EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000117859 OSBPL9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974187 View
ENSG00000101134 DOK5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974182 View
ENSG00000146648 EGFR ENSG00000171824 EXOSC10 H. sapiens SDL Slorth 0.97416 View
ENSG00000108179 PPIF ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974123 View
ENSG00000146648 EGFR ENSG00000213281 NRAS H. sapiens SDL Slorth 0.97412 View
ENSG00000146648 EGFR ENSG00000198554 WDHD1 H. sapiens SDL Slorth 0.974109 View
ENSG00000146648 EGFR ENSG00000173801 JUP H. sapiens SDL Slorth 0.974095 View
ENSG00000090020 SLC9A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974084 View
ENSG00000146648 EGFR ENSG00000167815 PRDX2 H. sapiens SDL Slorth 0.97408 View
ENSG00000146648 EGFR ENSG00000185104 FAF1 H. sapiens SDL Slorth 0.974076 View
ENSG00000029534 ANK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974063 View
ENSG00000032444 PNPLA6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974048 View
ENSG00000125107 CNOT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974034 View
ENSG00000136021 SCYL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974011 View
ENSG00000146648 EGFR ENSG00000164985 PSIP1 H. sapiens SDL Slorth 0.973975 View
ENSG00000072134 EPN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973964 View
ENSG00000115267 IFIH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973964 View
ENSG00000035403 VCL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973942 View
ENSG00000079950 STX7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973926 View
ENSG00000146648 EGFR ENSG00000198625 MDM4 H. sapiens SDL Slorth 0.973918 View
ENSG00000105063 PPP6R1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973912 View
ENSG00000095787 WAC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97391 View
ENSG00000146648 EGFR ENSG00000166333 ILK H. sapiens SDL Slorth 0.973896 View
ENSG00000028116 VRK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973877 View
ENSG00000146648 EGFR ENSG00000165025 SYK H. sapiens SDL Slorth 0.973824 View
ENSG00000146648 EGFR ENSG00000211456 SACM1L H. sapiens SDL Slorth 0.973806 View
ENSG00000146648 EGFR ENSG00000167996 FTH1 H. sapiens SDL Slorth 0.973806 View
ENSG00000107105 ELAVL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973786 View
ENSG00000116830 TTF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973785 View
ENSG00000075826 SEC31B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973784 View
ENSG00000073921 PICALM ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973742 View
ENSG00000079805 DNM2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973737 View
ENSG00000133835 HSD17B4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97369 View
ENSG00000089094 KDM2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973688 View
ENSG00000146648 EGFR ENSG00000164402 SEPT8 H. sapiens SDL Slorth 0.973666 View
ENSG00000146648 EGFR ENSG00000154447 SH3RF1 H. sapiens SDL Slorth 0.973662 View
ENSG00000146648 EGFR ENSG00000215301 DDX3X H. sapiens SDL Slorth 0.973642 View
ENSG00000000938 FGR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973634 View
ENSG00000099875 MKNK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973626 View
ENSG00000105369 CD79A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.973603 View