EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000152234 ATP5A1 H. sapiens SSL Slorth 0.915062 View
ENSG00000146648 EGFR ENSG00000170315 UBB H. sapiens SDL Slorth 0.915051 View
ENSG00000146648 EGFR ENSG00000185386 MAPK11 H. sapiens SDL Slorth 0.915041 View
ENSG00000146648 EGFR ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.915027 View
ENSG00000146648 EGFR ENSG00000179632 MAF1 H. sapiens SDL Slorth 0.914951 View
ENSG00000146648 EGFR ENSG00000178896 EXOSC4 H. sapiens SSL Slorth 0.914781 View
ENSG00000146648 EGFR ENSG00000151532 VTI1A H. sapiens SSL Slorth 0.914716 View
ENSG00000099624 ATP5D ENSG00000146648 EGFR H. sapiens SDL Slorth 0.91468 View
ENSG00000115170 ACVR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.914645 View
ENSG00000146648 EGFR ENSG00000177731 FLII H. sapiens SSL Slorth 0.914627 View
ENSG00000135972 MRPS9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.914525 View
ENSG00000146648 EGFR ENSG00000178691 SUZ12 H. sapiens SSL Slorth 0.914524 View
ENSG00000139112 GABARAPL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.91445 View
ENSG00000143379 SETDB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.914417 View
ENSG00000135999 EPC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.91418 View
ENSG00000146648 EGFR ENSG00000172367 PDZD3 H. sapiens SDL Slorth 0.91411 View
ENSG00000146648 EGFR ENSG00000205302 SNX2 H. sapiens SSL Slorth 0.913984 View
ENSG00000146648 EGFR ENSG00000164751 PEX2 H. sapiens SDL Slorth 0.913976 View
ENSG00000146648 EGFR ENSG00000172936 MYD88 H. sapiens SSL Slorth 0.913876 View
ENSG00000146648 EGFR ENSG00000164190 NIPBL H. sapiens SDL Slorth 0.913843 View
ENSG00000146648 EGFR ENSG00000152795 HNRNPDL H. sapiens SSL Slorth 0.913816 View
ENSG00000080503 SMARCA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.913671 View
ENSG00000146648 EGFR ENSG00000155959 VBP1 H. sapiens SDL Slorth 0.913559 View
ENSG00000108468 CBX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.913399 View
ENSG00000142534 RPS11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.913225 View
ENSG00000073578 SDHA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.913162 View
ENSG00000146648 EGFR ENSG00000163161 ERCC3 H. sapiens SSL Slorth 0.913078 View
ENSG00000146648 EGFR ENSG00000204103 MAFB H. sapiens SDL Slorth 0.912984 View
ENSG00000076003 MCM6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.912943 View
ENSG00000094804 CDC6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.912742 View
ENSG00000146648 EGFR ENSG00000183943 PRKX H. sapiens SDL Slorth 0.912562 View
ENSG00000146648 EGFR ENSG00000172354 GNB2 H. sapiens SDL Slorth 0.912387 View
ENSG00000146648 EGFR ENSG00000183765 CHEK2 H. sapiens SSL Slorth 0.912055 View
ENSG00000112576 CCND3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.911521 View
ENSG00000146648 EGFR ENSG00000167985 SDHAF2 H. sapiens SDL Slorth 0.911308 View
ENSG00000109670 FBXW7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.911289 View
ENSG00000054796 SPO11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.91116 View
ENSG00000146648 EGFR ENSG00000165409 TSHR H. sapiens SDL Slorth 0.911012 View
ENSG00000127152 BCL11B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.911011 View
ENSG00000139613 SMARCC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.910926 View