EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000155097 ATP6V1C1 H. sapiens SSL Slorth 0.91081 View
ENSG00000146648 EGFR ENSG00000148400 NOTCH1 H. sapiens SSL Slorth 0.910798 View
ENSG00000146648 EGFR ENSG00000182774 RPS17 H. sapiens SDL Slorth 0.910714 View
ENSG00000146648 EGFR ENSG00000165527 ARF6 H. sapiens SSL Slorth 0.910529 View
ENSG00000092010 PSME1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.910456 View
ENSG00000146648 EGFR ENSG00000162961 DPY30 H. sapiens SDL Slorth 0.910405 View
ENSG00000146648 EGFR ENSG00000155508 CNOT8 H. sapiens SSL Slorth 0.910318 View
ENSG00000071564 TCF3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.910217 View
ENSG00000146648 EGFR ENSG00000166710 B2M H. sapiens SDL Slorth 0.910132 View
ENSG00000146648 EGFR ENSG00000148730 EIF4EBP2 H. sapiens SDL Slorth 0.91007 View
ENSG00000146648 EGFR ENSG00000170473 PYM1 H. sapiens SSL Slorth 0.910063 View
ENSG00000146648 EGFR ENSG00000196781 TLE1 H. sapiens SDL Slorth 0.910034 View
ENSG00000108510 MED13 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.909946 View
ENSG00000146648 EGFR ENSG00000243056 EIF4EBP3 H. sapiens SDL Slorth 0.909914 View
ENSG00000146648 EGFR ENSG00000161547 SRSF2 H. sapiens SDL Slorth 0.909893 View
ENSG00000121481 RNF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.909717 View
ENSG00000104695 PPP2CB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.909568 View
ENSG00000118503 TNFAIP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.909282 View
ENSG00000146648 EGFR ENSG00000163482 STK36 H. sapiens SSL Slorth 0.909243 View
ENSG00000146648 EGFR ENSG00000177565 TBL1XR1 H. sapiens SSL Slorth 0.909206 View
ENSG00000109339 MAPK10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.909042 View
ENSG00000099804 CDC34 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.909033 View
ENSG00000146648 EGFR ENSG00000152818 UTRN H. sapiens SSL Slorth 0.909001 View
ENSG00000146648 EGFR ENSG00000185963 BICD2 H. sapiens SDL Slorth 0.90838 View
ENSG00000146648 EGFR ENSG00000168395 ING5 H. sapiens SSL Slorth 0.90835 View
ENSG00000146648 EGFR ENSG00000198791 CNOT7 H. sapiens SSL Slorth 0.908303 View
ENSG00000146648 EGFR ENSG00000165119 HNRNPK H. sapiens SDL Slorth 0.908247 View
ENSG00000125952 MAX ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9082 View
ENSG00000132170 PPARG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.908191 View
ENSG00000146648 EGFR ENSG00000172493 AFF1 H. sapiens SDL Slorth 0.908177 View
ENSG00000146648 EGFR ENSG00000170832 USP32 H. sapiens SSL Slorth 0.908172 View
ENSG00000146648 EGFR ENSG00000166888 STAT6 H. sapiens SDL Slorth 0.908101 View
ENSG00000146648 EGFR ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.907953 View
ENSG00000146648 EGFR ENSG00000165525 NEMF H. sapiens SDL Slorth 0.907804 View
ENSG00000146648 EGFR ENSG00000166233 ARIH1 H. sapiens SDL Slorth 0.907745 View
ENSG00000104142 VPS18 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.907603 View
ENSG00000146648 EGFR ENSG00000169249 ZRSR2 H. sapiens SDL Slorth 0.907422 View
ENSG00000146648 EGFR ENSG00000168214 RBPJ H. sapiens SSL Slorth 0.907412 View
ENSG00000146648 EGFR ENSG00000170776 AKAP13 H. sapiens SSL Slorth 0.907292 View
ENSG00000146648 EGFR ENSG00000168385 SEPT2 H. sapiens SSL Slorth 0.907107 View