BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000115317 HTRA2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.836736 View
ENSG00000077080 ACTL6B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.836346 View
ENSG00000131462 TUBG1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835716 View
ENSG00000005175 RPAP3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835675 View
ENSG00000083642 PDS5B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835666 View
ENSG00000132196 HSD17B7 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835612 View
ENSG00000106636 YKT6 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835539 View
ENSG00000118640 VAMP8 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835461 View
ENSG00000157764 BRAF ENSG00000185950 IRS2 H. sapiens SSL Slorth 0.835345 View
ENSG00000157764 BRAF ENSG00000167325 RRM1 H. sapiens SSL Slorth 0.835304 View
ENSG00000134371 CDC73 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835238 View
ENSG00000116898 MRPS15 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.835207 View
ENSG00000078668 VDAC3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.834996 View
ENSG00000113460 BRIX1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.834815 View
ENSG00000157764 BRAF ENSG00000198648 STK39 H. sapiens SSL Slorth 0.834319 View
ENSG00000066777 ARFGEF1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.83376 View
ENSG00000133119 RFC3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.833176 View
ENSG00000073584 SMARCE1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.83285 View
ENSG00000157764 BRAF ENSG00000177105 RHOG H. sapiens SSL Slorth 0.832767 View
ENSG00000157764 BRAF ENSG00000171132 PRKCE H. sapiens SSL Slorth 0.831571 View
ENSG00000157764 BRAF ENSG00000162409 PRKAA2 H. sapiens SSL Slorth 0.831414 View
ENSG00000080839 RBL1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.830869 View
ENSG00000023228 NDUFS1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.830616 View
ENSG00000122691 TWIST1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.830614 View
ENSG00000157764 BRAF ENSG00000244038 DDOST H. sapiens SSL Slorth 0.83061 View
ENSG00000157764 BRAF ENSG00000205220 PSMB10 H. sapiens SSL Slorth 0.830058 View
ENSG00000109819 PPARGC1A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.82995 View
ENSG00000039537 C6 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.829803 View
ENSG00000123908 AGO2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.82977 View
ENSG00000154174 TOMM70 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.82961 View
ENSG00000157764 BRAF ENSG00000180198 RCC1 H. sapiens SSL Slorth 0.828732 View
ENSG00000136574 GATA4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.828017 View
ENSG00000157764 BRAF ENSG00000166595 FAM96B H. sapiens SSL Slorth 0.82796 View
ENSG00000157764 BRAF ENSG00000170242 USP47 H. sapiens SSL Slorth 0.827763 View
ENSG00000157764 BRAF ENSG00000166797 FAM96A H. sapiens SSL Slorth 0.82769 View
ENSG00000116062 MSH6 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.827602 View
ENSG00000120616 EPC1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.827514 View
ENSG00000090316 MAEA ENSG00000157764 BRAF H. sapiens SSL Slorth 0.827254 View
ENSG00000137815 RTF1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.826974 View
ENSG00000113263 ITK ENSG00000157764 BRAF H. sapiens SSL Slorth 0.826461 View