BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157764 BRAF ENSG00000180370 PAK2 H. sapiens SDL Slorth 0.937049 View
ENSG00000157764 BRAF ENSG00000198400 NTRK1 H. sapiens SSL Slorth 0.936972 View
ENSG00000144554 FANCD2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.936915 View
ENSG00000157764 BRAF ENSG00000169756 LIMS1 H. sapiens SDL Slorth 0.936912 View
ENSG00000140396 NCOA2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.93681 View
ENSG00000157764 BRAF ENSG00000166598 HSP90B1 H. sapiens SDL Slorth 0.936626 View
ENSG00000157764 BRAF ENSG00000180008 SOCS4 H. sapiens SDL Slorth 0.936597 View
ENSG00000103197 TSC2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.936387 View
ENSG00000072310 SREBF1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.93599 View
ENSG00000130826 DKC1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.935856 View
ENSG00000157764 BRAF ENSG00000158186 MRAS H. sapiens SDL Slorth 0.935774 View
ENSG00000114742 WDR48 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.935422 View
ENSG00000134602 STK26 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.935298 View
ENSG00000157764 BRAF ENSG00000170836 PPM1D H. sapiens SDL Slorth 0.935241 View
ENSG00000119772 DNMT3A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.935101 View
ENSG00000105287 PRKD2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.935018 View
ENSG00000157764 BRAF ENSG00000181788 SIAH2 H. sapiens SSL Slorth 0.934995 View
ENSG00000115464 USP34 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.934875 View
ENSG00000157764 BRAF ENSG00000215301 DDX3X H. sapiens SSL Slorth 0.934872 View
ENSG00000129084 PSMA1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.934772 View
ENSG00000124813 RUNX2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.934659 View
ENSG00000026103 FAS ENSG00000157764 BRAF H. sapiens SSL Slorth 0.934404 View
ENSG00000080986 NDC80 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.934354 View
ENSG00000140443 IGF1R ENSG00000157764 BRAF H. sapiens SSL Slorth 0.934321 View
ENSG00000121481 RNF2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.9342 View
ENSG00000157764 BRAF ENSG00000175766 EIF4E1B H. sapiens SDL Slorth 0.934152 View
ENSG00000157764 BRAF ENSG00000160224 AIRE H. sapiens SDL Slorth 0.934128 View
ENSG00000101460 MAP1LC3A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.934116 View
ENSG00000140988 RPS2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.934079 View
ENSG00000157764 BRAF ENSG00000205531 NAP1L4 H. sapiens SSL Slorth 0.934054 View
ENSG00000157764 BRAF ENSG00000164924 YWHAZ H. sapiens SSL Slorth 0.934005 View
ENSG00000157764 BRAF ENSG00000174775 HRAS H. sapiens SSL Slorth 0.9338 View
ENSG00000051382 PIK3CB ENSG00000157764 BRAF H. sapiens SSL Slorth 0.93371 View
ENSG00000005007 UPF1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.933655 View
ENSG00000106299 WASL ENSG00000157764 BRAF H. sapiens SSL Slorth 0.933605 View
ENSG00000074211 PPP2R2C ENSG00000157764 BRAF H. sapiens SSL Slorth 0.933577 View
ENSG00000082898 XPO1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.933539 View
ENSG00000048052 HDAC9 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.933496 View
ENSG00000157764 BRAF ENSG00000183684 ALYREF H. sapiens SDL Slorth 0.933457 View
ENSG00000157764 BRAF ENSG00000159496 RGL4 H. sapiens SDL Slorth 0.933379 View