EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000107485 GATA3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975915 View
ENSG00000144034 TPRKB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975911 View
ENSG00000146648 EGFR ENSG00000168610 STAT3 H. sapiens SDL Slorth 0.97591 View
ENSG00000116729 WLS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975909 View
ENSG00000133318 RTN3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975909 View
ENSG00000138029 HADHB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975877 View
ENSG00000146648 EGFR ENSG00000173848 NET1 H. sapiens SDL Slorth 0.975875 View
ENSG00000130751 NPAS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975868 View
ENSG00000105245 NUMBL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97585 View
ENSG00000115290 GRB14 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975847 View
ENSG00000113368 LMNB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97582 View
ENSG00000141556 TBCD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975815 View
ENSG00000127914 AKAP9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975802 View
ENSG00000107819 SFXN3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975789 View
ENSG00000139797 RNF113B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975773 View
ENSG00000005156 LIG3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97576 View
ENSG00000140451 PIF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975711 View
ENSG00000116128 BCL9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975706 View
ENSG00000083750 RRAGB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975688 View
ENSG00000115616 SLC9A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975688 View
ENSG00000107862 GBF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975675 View
ENSG00000136758 YME1L1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975675 View
ENSG00000115073 ACTR1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975672 View
ENSG00000069345 DNAJA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975671 View
ENSG00000134215 VAV3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975653 View
ENSG00000115216 NRBP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975635 View
ENSG00000138095 LRPPRC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975587 View
ENSG00000146648 EGFR ENSG00000162367 TAL1 H. sapiens SDL Slorth 0.975575 View
ENSG00000078674 PCM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975573 View
ENSG00000141837 CACNA1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975569 View
ENSG00000125352 RNF113A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975543 View
ENSG00000104129 DNAJC17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975541 View
ENSG00000120149 MSX2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975492 View
ENSG00000070882 OSBPL3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975485 View
ENSG00000073712 FERMT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975485 View
ENSG00000135090 TAOK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975483 View
ENSG00000125733 TRIP10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975482 View
ENSG00000132437 DDC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975478 View
ENSG00000073614 KDM5A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975441 View
ENSG00000134698 AGO4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975408 View