TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000147133 TAF1 H. sapiens SSL Slorth 0.945369 View
ENSG00000110395 CBL ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.945363 View
ENSG00000131747 TOP2A ENSG00000132383 RPA1 H. sapiens SSL Slorth 0.945334 View
ENSG00000131747 TOP2A ENSG00000152601 MBNL1 H. sapiens SDL Slorth 0.945156 View
ENSG00000131747 TOP2A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945089 View
ENSG00000131747 TOP2A ENSG00000172732 MUS81 H. sapiens SDL Slorth 0.945084 View
ENSG00000104365 IKBKB ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.945073 View
ENSG00000131747 TOP2A ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.945025 View
ENSG00000131747 TOP2A ENSG00000136273 HUS1 H. sapiens SDL Slorth 0.944965 View
ENSG00000131747 TOP2A ENSG00000168283 BMI1 H. sapiens SSL Slorth 0.944963 View
ENSG00000131747 TOP2A ENSG00000158402 CDC25C H. sapiens SSL Slorth 0.94495 View
ENSG00000110092 CCND1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.944806 View
ENSG00000131747 TOP2A ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.944764 View
ENSG00000004487 KDM1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.944457 View
ENSG00000036257 CUL3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.944259 View
ENSG00000094916 CBX5 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.944045 View
ENSG00000131747 TOP2A ENSG00000198793 MTOR H. sapiens SSL Slorth 0.943764 View
ENSG00000073584 SMARCE1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.943721 View
ENSG00000071564 TCF3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.943663 View
ENSG00000103479 RBL2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.9436 View
ENSG00000131747 TOP2A ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.943415 View
ENSG00000105325 FZR1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.943302 View
ENSG00000131747 TOP2A ENSG00000147162 OGT H. sapiens SDL Slorth 0.943228 View
ENSG00000109971 HSPA8 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.943075 View
ENSG00000084676 NCOA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.943056 View
ENSG00000131747 TOP2A ENSG00000151692 RNF144A H. sapiens SDL Slorth 0.943045 View
ENSG00000131747 TOP2A ENSG00000134371 CDC73 H. sapiens SDL Slorth 0.942955 View
ENSG00000131747 TOP2A ENSG00000149480 MTA2 H. sapiens SSL Slorth 0.942937 View
ENSG00000131747 TOP2A ENSG00000213923 CSNK1E H. sapiens SSL Slorth 0.942731 View
ENSG00000131747 TOP2A ENSG00000144028 SNRNP200 H. sapiens SSL Slorth 0.94266 View
ENSG00000131747 TOP2A ENSG00000244687 UBE2V1 H. sapiens SSL Slorth 0.942476 View
ENSG00000131747 TOP2A ENSG00000244405 ETV5 H. sapiens SDL Slorth 0.942463 View
ENSG00000131747 TOP2A ENSG00000150907 FOXO1 H. sapiens SSL Slorth 0.942441 View
ENSG00000131747 TOP2A ENSG00000134982 APC H. sapiens SDL Slorth 0.942345 View
ENSG00000131747 TOP2A ENSG00000165025 SYK H. sapiens SSL Slorth 0.942203 View
ENSG00000085840 ORC1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.942154 View
ENSG00000131747 TOP2A ENSG00000140022 STON2 H. sapiens SDL Slorth 0.94208 View
ENSG00000131747 TOP2A ENSG00000172367 PDZD3 H. sapiens SDL Slorth 0.941822 View
ENSG00000131747 TOP2A ENSG00000161940 BCL6B H. sapiens SDL Slorth 0.941778 View
ENSG00000106355 LSM5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.941669 View