TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000116016 EPAS1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.96647 View
ENSG00000131747 TOP2A ENSG00000150991 UBC H. sapiens SDL Slorth 0.966398 View
ENSG00000131747 TOP2A ENSG00000149930 TAOK2 H. sapiens SDL Slorth 0.966272 View
ENSG00000131747 TOP2A ENSG00000141510 TP53 H. sapiens SDL Slorth 0.9662 View
ENSG00000104738 MCM4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.966135 View
ENSG00000123374 CDK2 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.966027 View
ENSG00000005007 UPF1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.966012 View
ENSG00000127511 SIN3B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965999 View
ENSG00000117676 RPS6KA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965815 View
ENSG00000061273 HDAC7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965708 View
ENSG00000113558 SKP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965488 View
ENSG00000113575 PPP2CA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965408 View
ENSG00000112118 MCM3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965333 View
ENSG00000082898 XPO1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965294 View
ENSG00000062822 POLD1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.965225 View
ENSG00000131747 TOP2A ENSG00000132646 PCNA H. sapiens SDL Slorth 0.965161 View
ENSG00000131747 TOP2A ENSG00000184937 WT1 H. sapiens SDL Slorth 0.965149 View
ENSG00000108443 RPS6KB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.96494 View
ENSG00000082898 XPO1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.964809 View
ENSG00000004700 RECQL ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.964245 View
ENSG00000123124 WWP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.964077 View
ENSG00000131747 TOP2A ENSG00000156299 TIAM1 H. sapiens SDL Slorth 0.963997 View
ENSG00000099956 SMARCB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.963828 View
ENSG00000131747 TOP2A ENSG00000143867 OSR1 H. sapiens SDL Slorth 0.963799 View
ENSG00000131747 TOP2A ENSG00000180900 SCRIB H. sapiens SDL Slorth 0.963763 View
ENSG00000131747 TOP2A ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.963655 View
ENSG00000082701 GSK3B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.963516 View
ENSG00000131747 TOP2A ENSG00000196419 XRCC6 H. sapiens SDL Slorth 0.963433 View
ENSG00000117748 RPA2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.9632 View
ENSG00000109906 ZBTB16 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.962949 View
ENSG00000131747 TOP2A ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.962805 View
ENSG00000131747 TOP2A ENSG00000131759 RARA H. sapiens SSL Slorth 0.962745 View
ENSG00000096384 HSP90AB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.962692 View
ENSG00000105810 CDK6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.96261 View
ENSG00000131747 TOP2A ENSG00000143556 S100A7 H. sapiens SDL Slorth 0.962549 View
ENSG00000131747 TOP2A ENSG00000169862 CTNND2 H. sapiens SDL Slorth 0.962507 View
ENSG00000131747 TOP2A ENSG00000141380 SS18 H. sapiens SDL Slorth 0.962443 View
ENSG00000131747 TOP2A ENSG00000160145 KALRN H. sapiens SDL Slorth 0.962323 View
ENSG00000131747 TOP2A ENSG00000185022 MAFF H. sapiens SDL Slorth 0.962322 View
ENSG00000091831 ESR1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.962282 View