TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000135090 TAOK3 H. sapiens SDL Slorth 0.954633 View
ENSG00000131747 TOP2A ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.954599 View
ENSG00000131747 TOP2A ENSG00000165115 KIF27 H. sapiens SDL Slorth 0.954582 View
ENSG00000131747 TOP2A ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.954484 View
ENSG00000123200 ZC3H13 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.95432 View
ENSG00000131747 TOP2A ENSG00000139687 RB1 H. sapiens SDL Slorth 0.954242 View
ENSG00000131747 TOP2A ENSG00000134086 VHL H. sapiens SSL Slorth 0.954219 View
ENSG00000105173 CCNE1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.954205 View
ENSG00000131747 TOP2A ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.954151 View
ENSG00000113456 RAD1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.954134 View
ENSG00000114062 UBE3A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.953991 View
ENSG00000131747 TOP2A ENSG00000169714 CNBP H. sapiens SDL Slorth 0.953918 View
ENSG00000023445 BIRC3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.953838 View
ENSG00000080503 SMARCA2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.953773 View
ENSG00000131747 TOP2A ENSG00000157168 NRG1 H. sapiens SDL Slorth 0.953658 View
ENSG00000131747 TOP2A ENSG00000185345 PARK2 H. sapiens SSL Slorth 0.953597 View
ENSG00000131747 TOP2A ENSG00000143799 PARP1 H. sapiens SSL Slorth 0.953319 View
ENSG00000131747 TOP2A ENSG00000164736 SOX17 H. sapiens SDL Slorth 0.953273 View
ENSG00000096968 JAK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.953099 View
ENSG00000131747 TOP2A ENSG00000142208 AKT1 H. sapiens SDL Slorth 0.953004 View
ENSG00000131747 TOP2A ENSG00000152284 TCF7L1 H. sapiens SDL Slorth 0.952841 View
ENSG00000127586 CHTF18 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.952809 View
ENSG00000131747 TOP2A ENSG00000173473 SMARCC1 H. sapiens SSL Slorth 0.952806 View
ENSG00000131747 TOP2A ENSG00000245848 CEBPA H. sapiens SSL Slorth 0.952789 View
ENSG00000119541 VPS4B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.952713 View
ENSG00000131747 TOP2A ENSG00000163098 BIRC8 H. sapiens SDL Slorth 0.952588 View
ENSG00000108094 CUL2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.952536 View
ENSG00000099804 CDC34 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.952497 View
ENSG00000115942 ORC2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.952465 View
ENSG00000106462 EZH2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.952333 View
ENSG00000131747 TOP2A ENSG00000138468 SENP7 H. sapiens SDL Slorth 0.952174 View
ENSG00000111875 ASF1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.951965 View
ENSG00000131747 TOP2A ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.951718 View
ENSG00000102978 POLR2C ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.951485 View
ENSG00000131747 TOP2A ENSG00000172059 KLF11 H. sapiens SDL Slorth 0.951332 View
ENSG00000131747 TOP2A ENSG00000165392 WRN H. sapiens SSL Slorth 0.951305 View
ENSG00000131747 TOP2A ENSG00000196419 XRCC6 H. sapiens SSL Slorth 0.950805 View
ENSG00000102882 MAPK3 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.950645 View
ENSG00000131747 TOP2A ENSG00000165684 SNAPC4 H. sapiens SDL Slorth 0.950088 View
ENSG00000131747 TOP2A ENSG00000134982 APC H. sapiens SSL Slorth 0.950076 View