TOP2A - TAF1

H. sapiens

SSL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2A	ENSG00000131747	No diseases in record	DAUNORUBICIN DOXORUBICIN EPIRUBICIN ETOPOSIDE ETOPOSIDE PHOSPHATE IDARUBICIN MITOXANTRONE PODOFILOX TENIPOSIDE VALRUBICIN	magnesium ion binding DNA binding chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending enzyme binding protein homodimerization activity histone deacetylase binding ubiquitin binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
TAF1	ENSG00000147133	No diseases in record	No drugs in record	RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly p53 binding transcription coactivator activity histone acetyltransferase activity protein serine/threonine kinase activity protein binding ATP binding transcription factor binding kinase activity TBP-class protein binding sequence-specific DNA binding protein heterodimerization activity ubiquitin conjugating enzyme activity lysine-acetylated histone binding acetyl-CoA binding transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly transcription regulatory region DNA binding transferase activity chromatin binding protein complex scaffold activity transferase activity, transferring acyl groups H4 histone acetyltransferase activity histone acetyltransferase activity (H3-K14 specific)	TAF1 (S. cerevisiae) taf-1 (C. elegans) Taf1 (D. melanogaster)