JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000162434 JAK1 ENSG00000198911 SREBF2 H. sapiens SSL Slorth 0.888875 View
ENSG00000100554 ATP6V1D ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.888361 View
ENSG00000112576 CCND3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.888126 View
ENSG00000113812 ACTR8 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.887989 View
ENSG00000160075 SSU72 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.887763 View
ENSG00000130713 EXOSC2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.887492 View
ENSG00000145375 SPATA5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.88727 View
ENSG00000157020 SEC13 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.886955 View
ENSG00000162434 JAK1 ENSG00000173110 HSPA6 H. sapiens SSL Slorth 0.88686 View
ENSG00000120837 NFYB ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.886736 View
ENSG00000091009 RBM27 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.886552 View
ENSG00000162434 JAK1 ENSG00000166200 COPS2 H. sapiens SSL Slorth 0.886329 View
ENSG00000092108 SCFD1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.88626 View
ENSG00000130811 EIF3G ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.885938 View
ENSG00000162434 JAK1 ENSG00000215301 DDX3X H. sapiens SSL Slorth 0.885763 View
ENSG00000108055 SMC3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.885551 View
ENSG00000101811 CSTF2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.885526 View
ENSG00000106070 GRB10 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.885263 View
ENSG00000122367 LDB3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.885163 View
ENSG00000075711 DLG1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.885119 View
ENSG00000162434 JAK1 ENSG00000164402 SEPT8 H. sapiens SSL Slorth 0.885062 View
ENSG00000114767 RRP9 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.884457 View
ENSG00000123349 PFDN5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.884454 View
ENSG00000155508 CNOT8 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.88391 View
ENSG00000162434 JAK1 ENSG00000196305 IARS H. sapiens SSL Slorth 0.883784 View
ENSG00000130396 AFDN ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.883651 View
ENSG00000115085 ZAP70 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.883366 View
ENSG00000162434 JAK1 ENSG00000163938 GNL3 H. sapiens SSL Slorth 0.882785 View
ENSG00000122257 RBBP6 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.882768 View
ENSG00000113013 HSPA9 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.882681 View
ENSG00000105647 PIK3R2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.88267 View
ENSG00000089289 IGBP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.882661 View
ENSG00000138071 ACTR2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.88194 View
ENSG00000162434 JAK1 ENSG00000162909 CAPN2 H. sapiens SSL Slorth 0.881933 View
ENSG00000121653 MAPK8IP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.881662 View
ENSG00000104852 SNRNP70 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.881495 View
ENSG00000010292 NCAPD2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.881317 View
ENSG00000133316 WDR74 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.881249 View
ENSG00000162434 JAK1 ENSG00000185104 FAF1 H. sapiens SSL Slorth 0.881223 View
ENSG00000123200 ZC3H13 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.880979 View