JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000152818 UTRN ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.912464 View
ENSG00000143322 ABL2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.912223 View
ENSG00000123159 GIPC1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.91215 View
ENSG00000162434 JAK1 ENSG00000172725 CORO1B H. sapiens SDL Slorth 0.912146 View
ENSG00000162434 JAK1 ENSG00000178568 ERBB4 H. sapiens SDL Slorth 0.911934 View
ENSG00000106245 BUD31 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.911818 View
ENSG00000119718 EIF2B2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.911683 View
ENSG00000160294 MCM3AP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.911678 View
ENSG00000076555 ACACB ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.911577 View
ENSG00000162434 JAK1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.911494 View
ENSG00000075089 ACTR6 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.911464 View
ENSG00000162434 JAK1 ENSG00000198648 STK39 H. sapiens SDL Slorth 0.911219 View
ENSG00000159263 SIM2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.911217 View
ENSG00000119335 SET ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.911069 View
ENSG00000162434 JAK1 ENSG00000175634 RPS6KB2 H. sapiens SDL Slorth 0.911036 View
ENSG00000138663 COPS4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.910736 View
ENSG00000126457 PRMT1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.91047 View
ENSG00000071242 RPS6KA2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.910006 View
ENSG00000162434 JAK1 ENSG00000196923 PDLIM7 H. sapiens SSL Slorth 0.909975 View
ENSG00000162434 JAK1 ENSG00000166913 YWHAB H. sapiens SDL Slorth 0.909691 View
ENSG00000107581 EIF3A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.909685 View
ENSG00000050820 BCAR1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.90948 View
ENSG00000162434 JAK1 ENSG00000204435 CSNK2B H. sapiens SDL Slorth 0.909283 View
ENSG00000162434 JAK1 ENSG00000168556 ING2 H. sapiens SSL Slorth 0.909221 View
ENSG00000158402 CDC25C ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.909201 View
ENSG00000162236 STX5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.908664 View
ENSG00000062650 WAPL ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.908613 View
ENSG00000155876 RRAGA ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.908463 View
ENSG00000130985 UBA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.908319 View
ENSG00000141646 SMAD4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.908166 View
ENSG00000162434 JAK1 ENSG00000179218 CALR H. sapiens SDL Slorth 0.908072 View
ENSG00000107872 FBXL15 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.90795 View
ENSG00000137693 YAP1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.907939 View
ENSG00000115020 PIKFYVE ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.907415 View
ENSG00000162434 JAK1 ENSG00000177189 RPS6KA3 H. sapiens SSL Slorth 0.907414 View
ENSG00000047249 ATP6V1H ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.90728 View
ENSG00000162434 JAK1 ENSG00000170035 UBE2E3 H. sapiens SSL Slorth 0.907176 View
ENSG00000074211 PPP2R2C ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.906972 View
ENSG00000007168 PAFAH1B1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.906969 View
ENSG00000087095 NLK ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.906939 View