TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000108055 SMC3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.867377 View
ENSG00000083520 DIS3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.866976 View
ENSG00000092531 SNAP23 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.866702 View
ENSG00000128739 SNRPN ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.866362 View
ENSG00000111877 MCM9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.866334 View
ENSG00000130713 EXOSC2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.86583 View
ENSG00000131747 TOP2A ENSG00000197579 TOPORS H. sapiens SSL Slorth 0.865765 View
ENSG00000075711 DLG1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.865691 View
ENSG00000053372 MRTO4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.865004 View
ENSG00000126524 SBDS ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.864822 View
ENSG00000131747 TOP2A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.864393 View
ENSG00000131747 TOP2A ENSG00000198561 CTNND1 H. sapiens SSL Slorth 0.864221 View
ENSG00000071242 RPS6KA2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.86381 View
ENSG00000117614 SYF2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.863451 View
ENSG00000131747 TOP2A ENSG00000163041 H3F3A H. sapiens SSL Slorth 0.862381 View
ENSG00000131747 TOP2A ENSG00000160294 MCM3AP H. sapiens SSL Slorth 0.862273 View
ENSG00000110955 ATP5B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.862096 View
ENSG00000104408 EIF3E ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.861984 View
ENSG00000131747 TOP2A ENSG00000163161 ERCC3 H. sapiens SSL Slorth 0.861973 View
ENSG00000125107 CNOT1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.861676 View
ENSG00000067606 PRKCZ ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.861629 View
ENSG00000109062 SLC9A3R1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.861562 View
ENSG00000131747 TOP2A ENSG00000170734 POLH H. sapiens SSL Slorth 0.861161 View
ENSG00000131747 TOP2A ENSG00000157557 ETS2 H. sapiens SSL Slorth 0.861118 View
ENSG00000033800 PIAS1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.860537 View
ENSG00000131747 TOP2A ENSG00000197122 SRC H. sapiens SSL Slorth 0.859557 View
ENSG00000131747 TOP2A ENSG00000177189 RPS6KA3 H. sapiens SSL Slorth 0.858711 View
ENSG00000124207 CSE1L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.858703 View
ENSG00000108590 MED31 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.857652 View
ENSG00000069399 BCL3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.85711 View
ENSG00000126215 XRCC3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.85672 View
ENSG00000108883 EFTUD2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.856206 View
ENSG00000126581 BECN1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.855466 View
ENSG00000095015 MAP3K1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.855397 View
ENSG00000077063 CTTNBP2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.855189 View
ENSG00000085832 EPS15 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.854885 View
ENSG00000131747 TOP2A ENSG00000177733 HNRNPA0 H. sapiens SSL Slorth 0.854254 View
ENSG00000131747 TOP2A ENSG00000156508 EEF1A1 H. sapiens SSL Slorth 0.853515 View
ENSG00000113812 ACTR8 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.852748 View
ENSG00000100028 SNRPD3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.852691 View