DIS3 - TOP2A

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
DIS3	ENSG00000083520	No diseases in record	No drugs in record	3'-5'-exoribonuclease activity RNA binding endonuclease activity guanyl-nucleotide exchange factor activity protein binding tRNA binding endoribonuclease activity nuclease activity exonuclease activity hydrolase activity nucleic acid binding exoribonuclease activity Ran GTPase binding ribonuclease activity	DIS3 (S. cerevisiae) dis-3 (C. elegans) Dis3 (D. melanogaster)
TOP2A	ENSG00000131747	No diseases in record	DAUNORUBICIN DOXORUBICIN EPIRUBICIN ETOPOSIDE ETOPOSIDE PHOSPHATE IDARUBICIN MITOXANTRONE PODOFILOX TENIPOSIDE VALRUBICIN	magnesium ion binding DNA binding chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending enzyme binding protein homodimerization activity histone deacetylase binding ubiquitin binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)