TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000138685 FGF2 H. sapiens SDL Slorth 0.903461 View
ENSG00000131747 TOP2A ENSG00000273841 TAF9 H. sapiens SSL Slorth 0.90343 View
ENSG00000101972 STAG2 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.903351 View
ENSG00000131747 TOP2A ENSG00000186575 NF2 H. sapiens SSL Slorth 0.903229 View
ENSG00000072310 SREBF1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.903221 View
ENSG00000131747 TOP2A ENSG00000178999 AURKB H. sapiens SSL Slorth 0.902765 View
ENSG00000068078 FGFR3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.902647 View
ENSG00000122565 CBX3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.902578 View
ENSG00000119772 DNMT3A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.902403 View
ENSG00000104852 SNRNP70 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.902276 View
ENSG00000106462 EZH2 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.902238 View
ENSG00000115816 CEBPZ ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.902219 View
ENSG00000131747 TOP2A ENSG00000177565 TBL1XR1 H. sapiens SDL Slorth 0.902181 View
ENSG00000084774 CAD ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.901701 View
ENSG00000131747 TOP2A ENSG00000153234 NR4A2 H. sapiens SDL Slorth 0.901663 View
ENSG00000131747 TOP2A ENSG00000166501 PRKCB H. sapiens SSL Slorth 0.901619 View
ENSG00000101412 E2F1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.901609 View
ENSG00000131747 TOP2A ENSG00000166949 SMAD3 H. sapiens SDL Slorth 0.901267 View
ENSG00000076555 ACACB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.901094 View
ENSG00000131747 TOP2A ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.900866 View
ENSG00000131747 TOP2A ENSG00000182606 TRAK1 H. sapiens SDL Slorth 0.900653 View
ENSG00000131747 TOP2A ENSG00000162775 RBM15 H. sapiens SDL Slorth 0.900274 View
ENSG00000131747 TOP2A ENSG00000131759 RARA H. sapiens SDL Slorth 0.900239 View
ENSG00000131747 TOP2A ENSG00000198373 WWP2 H. sapiens SDL Slorth 0.900021 View
ENSG00000131747 TOP2A ENSG00000159259 CHAF1B H. sapiens SSL Slorth 0.899893 View
ENSG00000131747 TOP2A ENSG00000196628 TCF4 H. sapiens SSL Slorth 0.899329 View
ENSG00000131747 TOP2A ENSG00000164362 TERT H. sapiens SSL Slorth 0.898981 View
ENSG00000131747 TOP2A ENSG00000138668 HNRNPD H. sapiens SSL Slorth 0.898789 View
ENSG00000130396 AFDN ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.898722 View
ENSG00000131747 TOP2A ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.898548 View
ENSG00000131747 TOP2A ENSG00000136518 ACTL6A H. sapiens SSL Slorth 0.898488 View
ENSG00000072518 MARK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.898015 View
ENSG00000131747 TOP2A ENSG00000136810 TXN H. sapiens SSL Slorth 0.897675 View
ENSG00000124181 PLCG1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.897183 View
ENSG00000080839 RBL1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.896834 View
ENSG00000087095 NLK ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.896637 View
ENSG00000131747 TOP2A ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.896526 View
ENSG00000122257 RBBP6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.896426 View
ENSG00000130826 DKC1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.895906 View
ENSG00000131747 TOP2A ENSG00000198668 CALM1 H. sapiens SSL Slorth 0.895878 View