POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000124813 RUNX2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.867434 View
ENSG00000047315 POLR2B ENSG00000177084 POLE H. sapiens SSL Slorth 0.867394 View
ENSG00000129691 ASH2L ENSG00000177084 POLE H. sapiens SSL Slorth 0.867126 View
ENSG00000099817 POLR2E ENSG00000177084 POLE H. sapiens SSL Slorth 0.866724 View
ENSG00000114742 WDR48 ENSG00000177084 POLE H. sapiens SSL Slorth 0.866072 View
ENSG00000102882 MAPK3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.865982 View
ENSG00000084676 NCOA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.865806 View
ENSG00000094880 CDC23 ENSG00000177084 POLE H. sapiens SSL Slorth 0.865686 View
ENSG00000177084 POLE ENSG00000177606 JUN H. sapiens SSL Slorth 0.864971 View
ENSG00000110330 BIRC2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.864666 View
ENSG00000177084 POLE ENSG00000187735 TCEA1 H. sapiens SSL Slorth 0.864584 View
ENSG00000130177 CDC16 ENSG00000177084 POLE H. sapiens SSL Slorth 0.864091 View
ENSG00000154582 TCEB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.86371 View
ENSG00000082898 XPO1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.863007 View
ENSG00000113575 PPP2CA ENSG00000177084 POLE H. sapiens SSL Slorth 0.862828 View
ENSG00000102978 POLR2C ENSG00000177084 POLE H. sapiens SSL Slorth 0.862573 View
ENSG00000106355 LSM5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.861288 View
ENSG00000177084 POLE ENSG00000245848 CEBPA H. sapiens SSL Slorth 0.860848 View
ENSG00000175792 RUVBL1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.860473 View
ENSG00000159692 CTBP1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.858934 View
ENSG00000060069 CTDP1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.858362 View
ENSG00000055332 EIF2AK2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.85826 View
ENSG00000172732 MUS81 ENSG00000177084 POLE H. sapiens SSL Slorth 0.857939 View
ENSG00000102054 RBBP7 ENSG00000177084 POLE H. sapiens SSL Slorth 0.857704 View
ENSG00000036257 CUL3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.857461 View
ENSG00000136628 EPRS ENSG00000177084 POLE H. sapiens SSL Slorth 0.856691 View
ENSG00000177084 POLE ENSG00000197442 MAP3K5 H. sapiens SSL Slorth 0.85648 View
ENSG00000142192 APP ENSG00000177084 POLE H. sapiens SSL Slorth 0.856231 View
ENSG00000051180 RAD51 ENSG00000177084 POLE H. sapiens SSL Slorth 0.856081 View
ENSG00000073969 NSF ENSG00000177084 POLE H. sapiens SSL Slorth 0.855804 View
ENSG00000004487 KDM1A ENSG00000177084 POLE H. sapiens SSL Slorth 0.85529 View
ENSG00000100142 POLR2F ENSG00000177084 POLE H. sapiens SSL Slorth 0.854739 View
ENSG00000143190 POU2F1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.854313 View
ENSG00000122512 PMS2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.854171 View
ENSG00000114867 EIF4G1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.853923 View
ENSG00000171148 TADA3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.853066 View
ENSG00000177084 POLE ENSG00000188612 SUMO2 H. sapiens SSL Slorth 0.853032 View
ENSG00000104738 MCM4 ENSG00000177084 POLE H. sapiens SSL Slorth 0.852388 View
ENSG00000101665 SMAD7 ENSG00000177084 POLE H. sapiens SSL Slorth 0.852342 View
ENSG00000177084 POLE ENSG00000185359 HGS H. sapiens SSL Slorth 0.852305 View